Rapid progression and brain atrophy in anti-AMPA receptor encephalitis

Yi Chia Wei; Chi Hung Liu; Jainn Jim Lin; Kun Ju Lin; Ko Lun Huang; Tsong Hai Lee; Yeu Jhy Chang; Tsung I. Peng; Kuang Lin Lin; Ting Yu Chang; Chien Hung Chang; Hung Chou Kuo; Kuo Hsuan Chang; Mei Yun Cheng; Chin Chang Huang

doi:10.1016/j.jneuroim.2013.05.011

Rapid progression and brain atrophy in anti-AMPA receptor encephalitis

Yi Chia Wei, Chi Hung Liu^*, Jainn Jim Lin, Kun Ju Lin, Ko Lun Huang, Tsong Hai Lee, Yeu Jhy Chang, Tsung I. Peng, Kuang Lin Lin, Ting Yu Chang, Chien Hung Chang, Hung Chou Kuo, Kuo Hsuan Chang, Mei Yun Cheng, Chin Chang Huang

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

52 Scopus citations

Abstract

Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is an anti-neuronal surface antigen autoimmune encephalitis that is rarely reported. Our study evaluated the first known patient who developed anti-AMPA receptor encephalitis during pregnancy. Initial brain MRI revealed bilateral limbic encephalitis. However, rapid brain atrophy on MRI with extensive hypometabolism of cerebral cortices, caudate nuclei and brain stem hypoperfusion on ¹⁸F-FDG PET developed when clinically progressed. IgG index of serial CSF studies reflected the clinical improvements after plasmapheresis and plasma exchange. The clinical spectrum of anti-AMPA receptor encephalitis may be expanded from limited limbic involvement to extended central nervous system.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	261
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.05.011
State	Published - 15 08 2013

Keywords

AMPA
Anti-glutamate receptor
Brain atrophy
Encephalitis
Eosinophilic meningoencephalitis

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10.1016/j.jneuroim.2013.05.011

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title = "Rapid progression and brain atrophy in anti-AMPA receptor encephalitis",

abstract = "Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is an anti-neuronal surface antigen autoimmune encephalitis that is rarely reported. Our study evaluated the first known patient who developed anti-AMPA receptor encephalitis during pregnancy. Initial brain MRI revealed bilateral limbic encephalitis. However, rapid brain atrophy on MRI with extensive hypometabolism of cerebral cortices, caudate nuclei and brain stem hypoperfusion on 18F-FDG PET developed when clinically progressed. IgG index of serial CSF studies reflected the clinical improvements after plasmapheresis and plasma exchange. The clinical spectrum of anti-AMPA receptor encephalitis may be expanded from limited limbic involvement to extended central nervous system.",

keywords = "AMPA, Anti-glutamate receptor, Brain atrophy, Encephalitis, Eosinophilic meningoencephalitis",

author = "Wei, {Yi Chia} and Liu, {Chi Hung} and Lin, {Jainn Jim} and Lin, {Kun Ju} and Huang, {Ko Lun} and Lee, {Tsong Hai} and Chang, {Yeu Jhy} and Peng, {Tsung I.} and Lin, {Kuang Lin} and Chang, {Ting Yu} and Chang, {Chien Hung} and Kuo, {Hung Chou} and Chang, {Kuo Hsuan} and Cheng, {Mei Yun} and Huang, {Chin Chang}",

year = "2013",

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doi = "10.1016/j.jneuroim.2013.05.011",

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AU - Wei, Yi Chia

AU - Liu, Chi Hung

AU - Lin, Jainn Jim

AU - Lin, Kun Ju

AU - Huang, Ko Lun

AU - Lee, Tsong Hai

AU - Chang, Yeu Jhy

AU - Peng, Tsung I.

AU - Lin, Kuang Lin

AU - Chang, Ting Yu

AU - Chang, Chien Hung

AU - Kuo, Hung Chou

AU - Chang, Kuo Hsuan

AU - Cheng, Mei Yun

AU - Huang, Chin Chang

PY - 2013/8/15

Y1 - 2013/8/15

N2 - Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is an anti-neuronal surface antigen autoimmune encephalitis that is rarely reported. Our study evaluated the first known patient who developed anti-AMPA receptor encephalitis during pregnancy. Initial brain MRI revealed bilateral limbic encephalitis. However, rapid brain atrophy on MRI with extensive hypometabolism of cerebral cortices, caudate nuclei and brain stem hypoperfusion on 18F-FDG PET developed when clinically progressed. IgG index of serial CSF studies reflected the clinical improvements after plasmapheresis and plasma exchange. The clinical spectrum of anti-AMPA receptor encephalitis may be expanded from limited limbic involvement to extended central nervous system.

AB - Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is an anti-neuronal surface antigen autoimmune encephalitis that is rarely reported. Our study evaluated the first known patient who developed anti-AMPA receptor encephalitis during pregnancy. Initial brain MRI revealed bilateral limbic encephalitis. However, rapid brain atrophy on MRI with extensive hypometabolism of cerebral cortices, caudate nuclei and brain stem hypoperfusion on 18F-FDG PET developed when clinically progressed. IgG index of serial CSF studies reflected the clinical improvements after plasmapheresis and plasma exchange. The clinical spectrum of anti-AMPA receptor encephalitis may be expanded from limited limbic involvement to extended central nervous system.

KW - AMPA

KW - Anti-glutamate receptor

KW - Brain atrophy

KW - Encephalitis

KW - Eosinophilic meningoencephalitis

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DO - 10.1016/j.jneuroim.2013.05.011

M3 - 文章

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AN - SCOPUS:84880818127

SN - 0165-5728

VL - 261

SP - 129

EP - 133

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Rapid progression and brain atrophy in anti-AMPA receptor encephalitis

Abstract

Keywords

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