Rare Occurrence of Aristolochic Acid Mutational Signatures in Oro-Gastrointestinal Tract Cancers

Abner Herbert Lim; Jason Yongsheng Chan; Ming Chin Yu; Tsung Han Wu; Jing Han Hong; Cedric Chuan Young Ng; Zhen Jie Low; Wei Liu; Rajasegaran Vikneswari; Pin Cheng Sung; Wen Lang Fan; Bin Tean Teh; Sen Yung Hsieh

doi:10.3390/cancers14030576

Rare Occurrence of Aristolochic Acid Mutational Signatures in Oro-Gastrointestinal Tract Cancers

Abner Herbert Lim, Jason Yongsheng Chan, Ming Chin Yu, Tsung Han Wu, Jing Han Hong, Cedric Chuan Young Ng, Zhen Jie Low, Wei Liu, Rajasegaran Vikneswari, Pin Cheng Sung, Wen Lang Fan, Bin Tean Teh^*, Sen Yung Hsieh^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

Background: Aristolochic acids (AAs) are potent mutagens commonly found in herbal plant-based remedies widely used throughout Asian countries. Patients and Methods: To understand whether AA is involved in the tumorigenesis of the oro-gastrointestinal tract, we used whole-exome sequencing to profile 54 cases of four distinct types of oro-gastrointestinal tract cancer (OGITC) from Taiwan. Results: A diverse landscape of mutational signatures including those from DNA mismatch repair and reactive oxygen species was observed. APOBEC mutational signatures were observed in 60% of oral squamous cell carcinomas. Only one sample harbored AA mutational signatures, contradictory to prior reports of cancers from Taiwan. The metabolism of AA in the liver and urinary tract, transient exposure time, and high cell turnover rates at OGITC sites may explain our findings. Conclusion: AA signatures in OGITCs are rare and unlikely to be a major contributing factor in oro-gastrointestinal tract tumorigenesis.

Original language	English
Article number	576
Journal	Cancers
Volume	14
Issue number	3
DOIs	https://doi.org/10.3390/cancers14030576
State	Published - 01 02 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Aristolochic acid
Carcinogens
Genomics
Mutagenesis
Next generation sequencing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers14030576

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@article{e5d7e0177f824b42b29b2d458e89618e,

title = "Rare Occurrence of Aristolochic Acid Mutational Signatures in Oro-Gastrointestinal Tract Cancers",

abstract = "Background: Aristolochic acids (AAs) are potent mutagens commonly found in herbal plant-based remedies widely used throughout Asian countries. Patients and Methods: To understand whether AA is involved in the tumorigenesis of the oro-gastrointestinal tract, we used whole-exome sequencing to profile 54 cases of four distinct types of oro-gastrointestinal tract cancer (OGITC) from Taiwan. Results: A diverse landscape of mutational signatures including those from DNA mismatch repair and reactive oxygen species was observed. APOBEC mutational signatures were observed in 60% of oral squamous cell carcinomas. Only one sample harbored AA mutational signatures, contradictory to prior reports of cancers from Taiwan. The metabolism of AA in the liver and urinary tract, transient exposure time, and high cell turnover rates at OGITC sites may explain our findings. Conclusion: AA signatures in OGITCs are rare and unlikely to be a major contributing factor in oro-gastrointestinal tract tumorigenesis.",

keywords = "Aristolochic acid, Carcinogens, Genomics, Mutagenesis, Next generation sequencing",

author = "Lim, {Abner Herbert} and Chan, {Jason Yongsheng} and Yu, {Ming Chin} and Wu, {Tsung Han} and Hong, {Jing Han} and Ng, {Cedric Chuan Young} and Low, {Zhen Jie} and Wei Liu and Rajasegaran Vikneswari and Sung, {Pin Cheng} and Fan, {Wen Lang} and Teh, {Bin Tean} and Hsieh, {Sen Yung}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = feb,

day = "1",

doi = "10.3390/cancers14030576",

language = "英语",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

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TY - JOUR

T1 - Rare Occurrence of Aristolochic Acid Mutational Signatures in Oro-Gastrointestinal Tract Cancers

AU - Lim, Abner Herbert

AU - Chan, Jason Yongsheng

AU - Yu, Ming Chin

AU - Wu, Tsung Han

AU - Hong, Jing Han

AU - Ng, Cedric Chuan Young

AU - Low, Zhen Jie

AU - Liu, Wei

AU - Vikneswari, Rajasegaran

AU - Sung, Pin Cheng

AU - Fan, Wen Lang

AU - Teh, Bin Tean

AU - Hsieh, Sen Yung

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Background: Aristolochic acids (AAs) are potent mutagens commonly found in herbal plant-based remedies widely used throughout Asian countries. Patients and Methods: To understand whether AA is involved in the tumorigenesis of the oro-gastrointestinal tract, we used whole-exome sequencing to profile 54 cases of four distinct types of oro-gastrointestinal tract cancer (OGITC) from Taiwan. Results: A diverse landscape of mutational signatures including those from DNA mismatch repair and reactive oxygen species was observed. APOBEC mutational signatures were observed in 60% of oral squamous cell carcinomas. Only one sample harbored AA mutational signatures, contradictory to prior reports of cancers from Taiwan. The metabolism of AA in the liver and urinary tract, transient exposure time, and high cell turnover rates at OGITC sites may explain our findings. Conclusion: AA signatures in OGITCs are rare and unlikely to be a major contributing factor in oro-gastrointestinal tract tumorigenesis.

AB - Background: Aristolochic acids (AAs) are potent mutagens commonly found in herbal plant-based remedies widely used throughout Asian countries. Patients and Methods: To understand whether AA is involved in the tumorigenesis of the oro-gastrointestinal tract, we used whole-exome sequencing to profile 54 cases of four distinct types of oro-gastrointestinal tract cancer (OGITC) from Taiwan. Results: A diverse landscape of mutational signatures including those from DNA mismatch repair and reactive oxygen species was observed. APOBEC mutational signatures were observed in 60% of oral squamous cell carcinomas. Only one sample harbored AA mutational signatures, contradictory to prior reports of cancers from Taiwan. The metabolism of AA in the liver and urinary tract, transient exposure time, and high cell turnover rates at OGITC sites may explain our findings. Conclusion: AA signatures in OGITCs are rare and unlikely to be a major contributing factor in oro-gastrointestinal tract tumorigenesis.

KW - Aristolochic acid

KW - Carcinogens

KW - Genomics

KW - Mutagenesis

KW - Next generation sequencing

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U2 - 10.3390/cancers14030576

DO - 10.3390/cancers14030576

M3 - 文章

AN - SCOPUS:85123275089

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 3

M1 - 576

ER -

Rare Occurrence of Aristolochic Acid Mutational Signatures in Oro-Gastrointestinal Tract Cancers

Abstract

Bibliographical note

Keywords

UN SDGs

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