TY - JOUR
T1 - Rationale and design of magnet (mitochondria-aging in northern Taiwan) study
T2 - A community-based cohort investigating mitochondria-related aging and cardiovascular diseases in suburban areas of Northern Taiwan
AU - Hung, Chung Lieh
AU - Wu, Yih Jer
AU - Liu, Chun Chieh
AU - Chi, Bo Chin
AU - Chang, Sheng Shiung
AU - Wang, Li Yu
AU - Yeh, Hung I.
AU - Wei, Yau Huei
PY - 2012/6
Y1 - 2012/6
N2 - Background: Aging is known to play a key role in the development of cardiovascular diseases (CVDs). Although aging is associated with mitochondria dysfunction, the impact of mitochondria-related aging on CVDs has remained unclear in Taiwan. Methods: The Mitochondria-AGing in NorthErn Taiwan (MAGNET) study, a prospective study, was initiated in December 2010 to investigate the prevalence, determinants and the progress of CVDs and related risks in a community-dwelling sample of about 3000 men and women from suburban areas of northern Taiwan. The middle-aged population comprises the majority of the whole cohort in a 3-year collection period. This study also examines a link between baseline characteristics and the development of subclinical atherosclerosis. Data obtained will include information regarding baseline demographics, body surface electrocardiography, blood bio-specimen components, measurement of cardiac and carotid structure and function by ultrasonography, socioeconomic status, life styles, and life quality scoring including short-form SF-36. Additional survey of blood samples, including analysis of endothelial progenitor cells and the mitochondria function, and biomarkers, for a nested case-control study will be performed. All participants will be followed for incidence and characterization of related cardiovascular events. Conclusion: This study is expected to clarify the role of mitochondria-related aging in the development of CVDs and functional changes in sub-urban areas of Taiwan.
AB - Background: Aging is known to play a key role in the development of cardiovascular diseases (CVDs). Although aging is associated with mitochondria dysfunction, the impact of mitochondria-related aging on CVDs has remained unclear in Taiwan. Methods: The Mitochondria-AGing in NorthErn Taiwan (MAGNET) study, a prospective study, was initiated in December 2010 to investigate the prevalence, determinants and the progress of CVDs and related risks in a community-dwelling sample of about 3000 men and women from suburban areas of northern Taiwan. The middle-aged population comprises the majority of the whole cohort in a 3-year collection period. This study also examines a link between baseline characteristics and the development of subclinical atherosclerosis. Data obtained will include information regarding baseline demographics, body surface electrocardiography, blood bio-specimen components, measurement of cardiac and carotid structure and function by ultrasonography, socioeconomic status, life styles, and life quality scoring including short-form SF-36. Additional survey of blood samples, including analysis of endothelial progenitor cells and the mitochondria function, and biomarkers, for a nested case-control study will be performed. All participants will be followed for incidence and characterization of related cardiovascular events. Conclusion: This study is expected to clarify the role of mitochondria-related aging in the development of CVDs and functional changes in sub-urban areas of Taiwan.
KW - aging
KW - cardiovascular diseases
KW - cohort study
KW - endothelial progenitor cells
KW - mitochondria
UR - http://www.scopus.com/inward/record.url?scp=84862842108&partnerID=8YFLogxK
U2 - 10.1016/j.ijge.2012.05.014
DO - 10.1016/j.ijge.2012.05.014
M3 - 文章
AN - SCOPUS:84862842108
SN - 1873-9598
VL - 6
SP - 122
EP - 126
JO - International Journal of Gerontology
JF - International Journal of Gerontology
IS - 2
ER -
