RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient

Hui Hua Hsiao; Ming Yu Yang; Yi Chang Liu; Hui Pin Hsiao; Shih Bin Tseng; Mei Chyn Chao; Ta Chih Liu; Sheng Fung Lin

doi:10.1002/ajh.20298

RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient

Hui Hua Hsiao
, Ming Yu Yang
, Yi Chang Liu
, Hui Pin Hsiao
, Shih Bin Tseng
, Mei Chyn Chao
, Ta Chih Liu
, Sheng Fung Lin^*

^*Corresponding author for this work

Kaohsiung Medical University

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

The t(1;22)(p13;q13) is a nonrandom chromosomal abnormality in acute leukemia with the fusion oncogene, RBM15-MKL1 (OTT-MAL), identified recently. However, this abnormality has been described only in infants and young children with acute megakaryoblastic leukemia (AMKL). We report a 59-year-old male patient with the diagnosis of acute myeloid leukemia, subtype M1, who harbors an abnormal chromosome +der(1)t(1;22)(p13;q13). The RBM15-MKL1 (OTT-MAL) fusion transcript was also confirmed by the reverse transcriptase-polymerase chain reaction. This unusual abnormality is rare in adult cases of leukemia, and in children it is restricted to AMKL. This report is accompanied by a review of the literature on the t(1;22)(p13;q13).

Original language	English
Pages (from-to)	43-45
Number of pages	3
Journal	American Journal of Hematology
Volume	79
Issue number	1
DOIs	https://doi.org/10.1002/ajh.20298
State	Published - 05 2005
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

AML
OTT-MAL
RBM15-MKL1
t(1;22)

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10.1002/ajh.20298

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@article{56f93d4473cf49d9beec5eab96d78567,

title = "RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient",

abstract = "The t(1;22)(p13;q13) is a nonrandom chromosomal abnormality in acute leukemia with the fusion oncogene, RBM15-MKL1 (OTT-MAL), identified recently. However, this abnormality has been described only in infants and young children with acute megakaryoblastic leukemia (AMKL). We report a 59-year-old male patient with the diagnosis of acute myeloid leukemia, subtype M1, who harbors an abnormal chromosome +der(1)t(1;22)(p13;q13). The RBM15-MKL1 (OTT-MAL) fusion transcript was also confirmed by the reverse transcriptase-polymerase chain reaction. This unusual abnormality is rare in adult cases of leukemia, and in children it is restricted to AMKL. This report is accompanied by a review of the literature on the t(1;22)(p13;q13).",

keywords = "AML, OTT-MAL, RBM15-MKL1, t(1;22)",

author = "Hsiao, \{Hui Hua\} and Yang, \{Ming Yu\} and Liu, \{Yi Chang\} and Hsiao, \{Hui Pin\} and Tseng, \{Shih Bin\} and Chao, \{Mei Chyn\} and Liu, \{Ta Chih\} and Lin, \{Sheng Fung\}",

year = "2005",

month = may,

doi = "10.1002/ajh.20298",

language = "英语",

volume = "79",

pages = "43--45",

journal = "American Journal of Hematology",

issn = "0361-8609",

publisher = "John Wiley and Sons Inc",

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TY - JOUR

T1 - RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient

AU - Hsiao, Hui Hua

AU - Yang, Ming Yu

AU - Liu, Yi Chang

AU - Hsiao, Hui Pin

AU - Tseng, Shih Bin

AU - Chao, Mei Chyn

AU - Liu, Ta Chih

AU - Lin, Sheng Fung

PY - 2005/5

Y1 - 2005/5

N2 - The t(1;22)(p13;q13) is a nonrandom chromosomal abnormality in acute leukemia with the fusion oncogene, RBM15-MKL1 (OTT-MAL), identified recently. However, this abnormality has been described only in infants and young children with acute megakaryoblastic leukemia (AMKL). We report a 59-year-old male patient with the diagnosis of acute myeloid leukemia, subtype M1, who harbors an abnormal chromosome +der(1)t(1;22)(p13;q13). The RBM15-MKL1 (OTT-MAL) fusion transcript was also confirmed by the reverse transcriptase-polymerase chain reaction. This unusual abnormality is rare in adult cases of leukemia, and in children it is restricted to AMKL. This report is accompanied by a review of the literature on the t(1;22)(p13;q13).

AB - The t(1;22)(p13;q13) is a nonrandom chromosomal abnormality in acute leukemia with the fusion oncogene, RBM15-MKL1 (OTT-MAL), identified recently. However, this abnormality has been described only in infants and young children with acute megakaryoblastic leukemia (AMKL). We report a 59-year-old male patient with the diagnosis of acute myeloid leukemia, subtype M1, who harbors an abnormal chromosome +der(1)t(1;22)(p13;q13). The RBM15-MKL1 (OTT-MAL) fusion transcript was also confirmed by the reverse transcriptase-polymerase chain reaction. This unusual abnormality is rare in adult cases of leukemia, and in children it is restricted to AMKL. This report is accompanied by a review of the literature on the t(1;22)(p13;q13).

KW - AML

KW - OTT-MAL

KW - RBM15-MKL1

KW - t(1;22)

UR - https://www.scopus.com/pages/publications/18044399163

U2 - 10.1002/ajh.20298

DO - 10.1002/ajh.20298

M3 - 文献综述

C2 - 15849773

AN - SCOPUS:18044399163

SN - 0361-8609

VL - 79

SP - 43

EP - 45

JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 1

ER -

RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient

Abstract

UN SDGs

Keywords

Access to Document

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