Recent advances in diabetic kidney diseases: From kidney injury to kidney fibrosis

Peir Haur Hung; Yung Chien Hsu; Tsung Hsien Chen; Chun Liang Lin

doi:10.3390/ijms222111857

Recent advances in diabetic kidney diseases: From kidney injury to kidney fibrosis

Peir Haur Hung
, Yung Chien Hsu
, Tsung Hsien Chen
, Chun Liang Lin^*

^*Corresponding author for this work

Chia-Yi Christian Hospital
Chia Nan University of Pharmacy and Science
Chang Gung Memorial Hospital
Chang Gung University

Research output: Contribution to journal › Review article › peer-review

139 Scopus citations

Abstract

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the de-tailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.

Original language	English
Article number	11857
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	21
DOIs	https://doi.org/10.3390/ijms222111857
State	Published - 01 11 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Albuminuria
Diabetic kidney disease
Fibrosis
Glomerulosclerosis
Inflammation

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10.3390/ijms222111857

Cite this

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title = "Recent advances in diabetic kidney diseases: From kidney injury to kidney fibrosis",

abstract = "Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the de-tailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.",

keywords = "Albuminuria, Diabetic kidney disease, Fibrosis, Glomerulosclerosis, Inflammation",

author = "Hung, \{Peir Haur\} and Hsu, \{Yung Chien\} and Chen, \{Tsung Hsien\} and Lin, \{Chun Liang\}",

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doi = "10.3390/ijms222111857",

language = "英语",

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TY - JOUR

T1 - Recent advances in diabetic kidney diseases

T2 - From kidney injury to kidney fibrosis

AU - Hung, Peir Haur

AU - Hsu, Yung Chien

AU - Chen, Tsung Hsien

AU - Lin, Chun Liang

PY - 2021/11/1

Y1 - 2021/11/1

N2 - Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the de-tailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.

AB - Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the de-tailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.

KW - Albuminuria

KW - Diabetic kidney disease

KW - Fibrosis

KW - Glomerulosclerosis

KW - Inflammation

UR - https://www.scopus.com/pages/publications/85118207285

U2 - 10.3390/ijms222111857

DO - 10.3390/ijms222111857

M3 - 文献综述

C2 - 34769288

AN - SCOPUS:85118207285

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 21

M1 - 11857

ER -

Recent advances in diabetic kidney diseases: From kidney injury to kidney fibrosis

Abstract

Bibliographical note

UN SDGs

Keywords

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