Recent progresses in gene delivery-based bone tissue engineering

Chia Hsin Lu; Yu Han Chang; Shih Yeh Lin; Kuei Chang Li; Yu Chen Hu

doi:10.1016/j.biotechadv.2013.08.015

Recent progresses in gene delivery-based bone tissue engineering

Chia Hsin Lu, Yu Han Chang, Shih Yeh Lin, Kuei Chang Li, Yu Chen Hu^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Review article › peer-review

105 Scopus citations

Abstract

Gene therapy has converged with bone engineering over the past decade, by which a variety of therapeutic genes have been delivered to stimulate bone repair. These genes can be administered via in vivo or ex vivo approach using either viral or nonviral vectors. This article reviews the fundamental aspects and recent progresses in the gene therapy-based bone engineering, with emphasis on the new genes, viral vectors and gene delivery approaches.

Original language	English
Pages (from-to)	1695-1706
Number of pages	12
Journal	Biotechnology Advances
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.biotechadv.2013.08.015
State	Published - 12 2013

Keywords

Bone
Gene delivery approach
Gene therapy
Regenerative medicine
Stem cell
Tissue engineering
Viral vectors

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10.1016/j.biotechadv.2013.08.015

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title = "Recent progresses in gene delivery-based bone tissue engineering",

abstract = "Gene therapy has converged with bone engineering over the past decade, by which a variety of therapeutic genes have been delivered to stimulate bone repair. These genes can be administered via in vivo or ex vivo approach using either viral or nonviral vectors. This article reviews the fundamental aspects and recent progresses in the gene therapy-based bone engineering, with emphasis on the new genes, viral vectors and gene delivery approaches.",

keywords = "Bone, Gene delivery approach, Gene therapy, Regenerative medicine, Stem cell, Tissue engineering, Viral vectors",

author = "Lu, {Chia Hsin} and Chang, {Yu Han} and Lin, {Shih Yeh} and Li, {Kuei Chang} and Hu, {Yu Chen}",

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AU - Chang, Yu Han

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AU - Li, Kuei Chang

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AB - Gene therapy has converged with bone engineering over the past decade, by which a variety of therapeutic genes have been delivered to stimulate bone repair. These genes can be administered via in vivo or ex vivo approach using either viral or nonviral vectors. This article reviews the fundamental aspects and recent progresses in the gene therapy-based bone engineering, with emphasis on the new genes, viral vectors and gene delivery approaches.

KW - Bone

KW - Gene delivery approach

KW - Gene therapy

KW - Regenerative medicine

KW - Stem cell

KW - Tissue engineering

KW - Viral vectors

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M3 - 文献综述

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JO - Biotechnology Advances

JF - Biotechnology Advances

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Recent progresses in gene delivery-based bone tissue engineering

Abstract

Keywords

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