Recent progresses in gene delivery-based bone tissue engineering

Chia Hsin Lu, Yu Han Chang, Shih Yeh Lin, Kuei Chang Li, Yu Chen Hu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

103 Scopus citations

Abstract

Gene therapy has converged with bone engineering over the past decade, by which a variety of therapeutic genes have been delivered to stimulate bone repair. These genes can be administered via in vivo or ex vivo approach using either viral or nonviral vectors. This article reviews the fundamental aspects and recent progresses in the gene therapy-based bone engineering, with emphasis on the new genes, viral vectors and gene delivery approaches.

Original languageEnglish
Pages (from-to)1695-1706
Number of pages12
JournalBiotechnology Advances
Volume31
Issue number8
DOIs
StatePublished - 12 2013

Keywords

  • Bone
  • Gene delivery approach
  • Gene therapy
  • Regenerative medicine
  • Stem cell
  • Tissue engineering
  • Viral vectors

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