Receptors and ligands involved in viral induction of type I interferon production by plasmacytoid dendritic cells

Rosalind E. Seeds, Siamon Gordon, Joanna L. Miller*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

18 Scopus citations

Abstract

Virus infection is sensed by the innate immune system which then rapidly initiates biosynthesis of type I interferon (IFN). The IFN signaling systems produce a broadly effective innate antiviral response by creating an antiviral state in both an autocrine and paracrine manner in cells and by activating innate and adaptive immunity. Plasmacytoid dendritic cells (pDCs) have the unique ability to produce very high levels of type I IFN following viral infection in vivo. Most recent research has focused on oligonucleotide-mediated induction of type I IFN production, implicating viral genome and replication intermediates as the stimulus for this response. However there are additional viral ligands which can potentially induce type I IFN production in pDCs, such as envelope glycoproteins, viral glycolipids, tegument, capsid or nuclear proteins. This area of viral immunology, which has been neglected in the literature, will be discussed here.

Original languageEnglish
Pages (from-to)525-535
Number of pages11
JournalImmunobiology
Volume211
Issue number6-8
DOIs
StatePublished - 14 09 2006
Externally publishedYes

Keywords

  • Plasmacytoid dendritic cells
  • Type I interferon
  • Viral glycoprotein

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