Recognition rate advancement and data error improvement of pathology cutting with h-denseunet for hepatocellular carcinoma image

Wen Fan Chen, Hsin You Ou, Cheng Tang Pan, Chien Chang Liao, Wen Huang, Han Yu Lin, Yu Fan Cheng*, Chia Po Wei*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


Due to the fact that previous studies have rarely investigated the recognition rate discrepancy and pathology data error when applied to different databases, the purpose of this study is to investigate the improvement of recognition rate via deep learning-based liver lesion segmentation with the incorporation of hospital data. The recognition model used in this study is H-DenseUNet, which is applied to the segmentation of the liver and lesions, and a mixture of 2D/3D Hybrid-DenseUNet is used to reduce the recognition time and system memory requirements. Differences in recognition results were determined by comparing the training files of the standard LiTS competition data set with the training set after mixing in an additional 30 patients. The average error value of 9.6% was obtained by comparing the data discrepancy between the actual pathology data and the pathology data after the analysis of the identified images imported from Kaohsiung Chang Gung Memorial Hospital. The average error rate of the recognition output after mixing the LiTS database with hospital data for training was 1%. In the recognition part, the Dice coefficient was 0.52 after training 50 epochs using the standard LiTS database, while the Dice coefficient was increased to 0.61 after adding 30 hospital data to the training. After importing 3D Slice and ITK-Snap software, a 3D image of the lesion and liver segmentation can be developed. It is hoped that this method could be used to stimulate more research in addition to the general public standard database in the future, as well as to study the applicability of hospital data and improve the generality of the database.

Original languageEnglish
Article number1599
Issue number9
StatePublished - 09 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Data comparison
  • Deep learning
  • H-DenseUNet
  • Lesion segmentation
  • Liver segmentation
  • Medical statistics
  • Pathological


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