TY - JOUR
T1 - Recognizing death
T2 - The phagocytosis of apoptotic cells
AU - Platt, Nick
AU - Da Silva, Rosangela P.
AU - Gordon, Siamon
PY - 1998/9/1
Y1 - 1998/9/1
N2 - Although apoptotic cell death is widespread, dying cells are rarely seen in situ because of their rapid clearance by neighbouring phagocytes. Phagocytic recognition of apoptotic cells is less well understood than the death programme itself, but an increasing number of recent studies are highlighting its importance. This review discusses the nature of the receptors that have been implicated in apoptotic cell phagocytosis, the mechanisms of uptake and the immunological consequences of apoptotic cell ingestion.
AB - Although apoptotic cell death is widespread, dying cells are rarely seen in situ because of their rapid clearance by neighbouring phagocytes. Phagocytic recognition of apoptotic cells is less well understood than the death programme itself, but an increasing number of recent studies are highlighting its importance. This review discusses the nature of the receptors that have been implicated in apoptotic cell phagocytosis, the mechanisms of uptake and the immunological consequences of apoptotic cell ingestion.
UR - http://www.scopus.com/inward/record.url?scp=0032169220&partnerID=8YFLogxK
U2 - 10.1016/S0962-8924(98)01329-4
DO - 10.1016/S0962-8924(98)01329-4
M3 - 文献综述
C2 - 9728398
AN - SCOPUS:0032169220
SN - 0962-8924
VL - 8
SP - 365
EP - 372
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 9
ER -