Recommendations for the use of Japanese encephalitis vaccines

Ping Ing Lee*, Yhu Chering Huang, Kao Pin Hwang, Ching Chuan Liu, Cheng Hsun Chiu, Po Yen Chen, Chun Yi Lu, Chih Jung Chen, Luan Yin Chang, Nan Chang Chiu, Hsin Chi, Hsiao Chuan Lin, Keh Gong Wu, Yu Huai Ho, Wu Sun, Tzou Yien Lin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Japanese encephalitis (JE) is a mosquito-borne viral infection which is prevalent in Taiwan. The virus circulates in an enzootic cycle in pigs which serve as amplifying hosts. Outbreaks typically occur during summer. A universal vaccination program using 4-shot mouse brain-derived inactivated vaccine has successfully controlled JE epidemics in Taiwan since 1968. More than 90% of JE cases in recent years were older than 20 years in Taiwan. Because of several drawbacks, mouse brain-derived vaccine has been replaced by newer generation JE vaccines, including inactivated Vero cell-derived vaccine and live chimeric vaccine. The present article describes the recommendations in Taiwan for the use of new JE vaccines and the schedules for shifting between different JE vaccines.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalPediatrics and Neonatology
Issue number1
StatePublished - 02 2020

Bibliographical note

Publisher Copyright:
© 2019


  • Japanese encephalitis
  • epidemiology
  • immunization schedule
  • vaccination


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