Recommended guidelines for use of intravitreal aflibercept with a treat-And-extend regimen for the management of neovascular age-related macular degeneration in the Asia-pacific region: Report from a consensus panel

Adrian Koh*, Paolo Lanzetta, Won Ki Lee, Chi Chun Lai, Wai Man Chan, Chung May Yang, Chui Ming Gemmy Cheung

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Purpose: To summarize recommendations for the use of intravitreal aflibercept with a treat-And-extend regimen to manage neovascular age-related macular degeneration (nAMD) in the Asia-Pacific region. Although anti-vascular endothelial growth factor therapies have improved the quality of life of patients with nAMD, a leading cause of blindness and visual impairment, the high treatment frequency recommended by current guidelines places a significant burden on patients and healthcare providers. Design: Recommended guidelines from a consensus panel.Methods: An expert panel formed a consensus on recommendations for use of intravitreal aflibercept as treatment of nAMD in the Asia-Pacific region.Results: After 3 initial monthly doses, treatment interval could be extended by 4-week increments, to a maximum of 12 weeks, in patients with inactive disease. Conversely, in active disease, treatment intervals should be shortened, by 4 weeks, or to 4 weeks in cases of severe recurrence. Treatment could be ceased in patients with stable disease activity after 12 months of treatment at 12-week intervals, as a means to prevent over treatment and lifelong injections.Conclusions: These recommendations could potentially minimize the number of treatments while maintaining efficacy and improve compliance by reducing the number of clinic visits compared with existing recommendations.

Original languageEnglish
Pages (from-to)296-302
Number of pages7
JournalAsia-Pacific Journal of Ophthalmology
Volume6
Issue number3
DOIs
StatePublished - 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 by Asia Pacific Academy of Ophthalmology.

Keywords

  • Aflibercept
  • Age-related macular degeneration
  • Asia
  • Blindness
  • Vascular endothelial growth factor

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