Recurrent alcaligenes xylosoxidans keratitis

Zei Lun Huang, Yeong Fong Chen, Shu Wen Chang, Ken Kuo Lin, Ching Hsi Hsiao*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

12 Scopus citations


Purpose: To describe a case of postkeratoplasty recurrent Alcaligenes xylosoxidans keratitis. Methods: A 33-year-old man with a history of penetrating keratoplasty developed corneal infiltrate with intact epithelium and then was treated with broad-spectrum antibiotics. Corneal scraping was taken for microbiologic study. Results: The culture result identified A. xylosoxidans, sensitive to piperacillin and ceftazidime. There were 3 recurrent episodes within 2 months after each apparent resolution achieved after the instillation of topical piperacillin (10 mg/mL). During the fourth attack, the lesion responded poorly to piperacillin and ceftazidime (25 mg/mL), so therapeutic penetrating keratoplasty was performed to eradicate the recalcitrant infection. Conclusions: A. xylosoxidans has probably been underreported as a cause of ocular infection. It does not respond to conventional antibiotic therapy and may be difficult to eradicate. Therapeutic penetrating keratoplasty might be necessary if medical treatment fails.

Original languageEnglish
Pages (from-to)489-490
Number of pages2
Issue number4
StatePublished - 05 2005
Externally publishedYes


  • Alcaligenes xylosoxidans
  • Recurrent keratitis
  • Therapeutic penetrating keratoplasty


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