TY - JOUR
T1 - Red cell distribution width associated with adverse cardiovascular outcomes in patients with chronic kidney disease
AU - Lu, Yueh An
AU - Fan, Pei Chun
AU - Lee, Cheng Chia
AU - Wu, Victor Chien Chia
AU - Tian, Ya Chung
AU - Yang, Chih Wei
AU - Chen, Yung Chang
AU - Chang, Chih Hsiang
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/13
Y1 - 2017/12/13
N2 - Background: Recent studies have demonstrated that red cell distribution width (RDW) is associated with cardiovascular (CV) events and mortality. Patients with chronic kidney disease (CKD) are often anemic and have high RDW levels. In this study, we investigated the effect of RDW on major composite CV outcomes among patients with CKD. Methods: We retrospectively analyzed patients with CKD who were admitted to the department of cardiology of a tertiary hospital in 2011. The patients were divided into 2 groups: normal RDW (RDW < 14.5%) and elevated RDW (RDW ≥ 14.5%). Demographic characteristics, comorbidities, blood investigation results, prescriptions, and outcomes were analyzed after a 3-year follow-up period. Six adjustment levels were performed to evaluate the effect of RDW on outcomes. Results: This study involved 282 patients with CKD: 213 in the elevated RDW group and 69 in the normal RDW group. The elevated RDW group had older patients, a lower proportion of male patients, lower left ventricular ejection fraction (LVEF) values, lower hemoglobin levels, lower serum albumin levels, and higher creatinine levels, compared with the normal RDW group. A linear trend was observed toward higher RDW in patients with deteriorating renal function. In the final adjusted model, RDW ≥ 14.5%, older age, and lower LVEF were associated with an increased risk of major composite CV outcomes. Conclusion: RDW is a potentially useful cost-effective indicator of major composite CV outcomes in patients with CKD.
AB - Background: Recent studies have demonstrated that red cell distribution width (RDW) is associated with cardiovascular (CV) events and mortality. Patients with chronic kidney disease (CKD) are often anemic and have high RDW levels. In this study, we investigated the effect of RDW on major composite CV outcomes among patients with CKD. Methods: We retrospectively analyzed patients with CKD who were admitted to the department of cardiology of a tertiary hospital in 2011. The patients were divided into 2 groups: normal RDW (RDW < 14.5%) and elevated RDW (RDW ≥ 14.5%). Demographic characteristics, comorbidities, blood investigation results, prescriptions, and outcomes were analyzed after a 3-year follow-up period. Six adjustment levels were performed to evaluate the effect of RDW on outcomes. Results: This study involved 282 patients with CKD: 213 in the elevated RDW group and 69 in the normal RDW group. The elevated RDW group had older patients, a lower proportion of male patients, lower left ventricular ejection fraction (LVEF) values, lower hemoglobin levels, lower serum albumin levels, and higher creatinine levels, compared with the normal RDW group. A linear trend was observed toward higher RDW in patients with deteriorating renal function. In the final adjusted model, RDW ≥ 14.5%, older age, and lower LVEF were associated with an increased risk of major composite CV outcomes. Conclusion: RDW is a potentially useful cost-effective indicator of major composite CV outcomes in patients with CKD.
KW - Cardiovascular outcomes
KW - Chronic kidney disease
KW - Red cell distribution width
UR - https://www.scopus.com/pages/publications/85037999805
U2 - 10.1186/s12882-017-0766-4
DO - 10.1186/s12882-017-0766-4
M3 - 文章
C2 - 29237417
AN - SCOPUS:85037999805
SN - 1471-2369
VL - 18
JO - BMC Nephrology
JF - BMC Nephrology
IS - 1
M1 - 361
ER -
