Redox-responsive dasatinib-containing hyaluronic acid prodrug and co-delivery of doxorubicin for cancer therapy

Yin Ku Lin; Shiu Wei Wang; Ren Shen Lee

doi:10.1080/00914037.2020.1798434

Redox-responsive dasatinib-containing hyaluronic acid prodrug and co-delivery of doxorubicin for cancer therapy

Yin Ku Lin, Shiu Wei Wang, Ren Shen Lee^*

^*Corresponding author for this work

Center for General Education

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

Redox-responsive prodrugs were synthesized by conjugating dasatinib (Das)/cholesterol (Chol) to hyaluronic acid (HA) via the cystamine dihydrochloride (Cys), and hexamethylene diamine (Hda) linkers. In a redox environment (10 mM dithiothreitol, DTT), a substantial amount of the grafted Das was released and faster than that observed under physiological conditions. The cytotoxicity of redox-sensitive HA-Cys-P(SSDas/CCChol) was greater than that of redox-insensitive HA-Hda-PCCDas. Flow cytometry showed that the uptake of HA-targeted DOX–encapsulated micelles was faster than that of free DOX.

Original language	English
Pages (from-to)	1329-1343
Number of pages	15
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	70
Issue number	18
DOIs	https://doi.org/10.1080/00914037.2020.1798434
State	Published - 2021

Bibliographical note

Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.

Keywords

Prodrug
dasatinib
hyaluronic acid
redox-responsive

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/00914037.2020.1798434

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title = "Redox-responsive dasatinib-containing hyaluronic acid prodrug and co-delivery of doxorubicin for cancer therapy",

abstract = "Redox-responsive prodrugs were synthesized by conjugating dasatinib (Das)/cholesterol (Chol) to hyaluronic acid (HA) via the cystamine dihydrochloride (Cys), and hexamethylene diamine (Hda) linkers. In a redox environment (10 mM dithiothreitol, DTT), a substantial amount of the grafted Das was released and faster than that observed under physiological conditions. The cytotoxicity of redox-sensitive HA-Cys-P(SSDas/CCChol) was greater than that of redox-insensitive HA-Hda-PCCDas. Flow cytometry showed that the uptake of HA-targeted DOX–encapsulated micelles was faster than that of free DOX.",

keywords = "Prodrug, dasatinib, hyaluronic acid, redox-responsive",

author = "Lin, {Yin Ku} and Wang, {Shiu Wei} and Lee, {Ren Shen}",

note = "Publisher Copyright: {\textcopyright} 2020 Taylor & Francis Group, LLC.",

year = "2021",

doi = "10.1080/00914037.2020.1798434",

language = "英语",

volume = "70",

pages = "1329--1343",

journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",

issn = "0091-4037",

publisher = "Taylor and Francis Ltd.",

number = "18",

}

TY - JOUR

T1 - Redox-responsive dasatinib-containing hyaluronic acid prodrug and co-delivery of doxorubicin for cancer therapy

AU - Lin, Yin Ku

AU - Wang, Shiu Wei

AU - Lee, Ren Shen

PY - 2021

Y1 - 2021

N2 - Redox-responsive prodrugs were synthesized by conjugating dasatinib (Das)/cholesterol (Chol) to hyaluronic acid (HA) via the cystamine dihydrochloride (Cys), and hexamethylene diamine (Hda) linkers. In a redox environment (10 mM dithiothreitol, DTT), a substantial amount of the grafted Das was released and faster than that observed under physiological conditions. The cytotoxicity of redox-sensitive HA-Cys-P(SSDas/CCChol) was greater than that of redox-insensitive HA-Hda-PCCDas. Flow cytometry showed that the uptake of HA-targeted DOX–encapsulated micelles was faster than that of free DOX.

AB - Redox-responsive prodrugs were synthesized by conjugating dasatinib (Das)/cholesterol (Chol) to hyaluronic acid (HA) via the cystamine dihydrochloride (Cys), and hexamethylene diamine (Hda) linkers. In a redox environment (10 mM dithiothreitol, DTT), a substantial amount of the grafted Das was released and faster than that observed under physiological conditions. The cytotoxicity of redox-sensitive HA-Cys-P(SSDas/CCChol) was greater than that of redox-insensitive HA-Hda-PCCDas. Flow cytometry showed that the uptake of HA-targeted DOX–encapsulated micelles was faster than that of free DOX.

KW - Prodrug

KW - dasatinib

KW - hyaluronic acid

KW - redox-responsive

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U2 - 10.1080/00914037.2020.1798434

DO - 10.1080/00914037.2020.1798434

M3 - 文章

AN - SCOPUS:85088835531

SN - 0091-4037

VL - 70

SP - 1329

EP - 1343

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

IS - 18

ER -

Redox-responsive dasatinib-containing hyaluronic acid prodrug and co-delivery of doxorubicin for cancer therapy

Abstract

Bibliographical note

Keywords

UN SDGs

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