Abstract
Redox-responsive prodrugs were synthesized by conjugating dasatinib (Das)/cholesterol (Chol) to hyaluronic acid (HA) via the cystamine dihydrochloride (Cys), and hexamethylene diamine (Hda) linkers. In a redox environment (10 mM dithiothreitol, DTT), a substantial amount of the grafted Das was released and faster than that observed under physiological conditions. The cytotoxicity of redox-sensitive HA-Cys-P(SSDas/CCChol) was greater than that of redox-insensitive HA-Hda-PCCDas. Flow cytometry showed that the uptake of HA-targeted DOX–encapsulated micelles was faster than that of free DOX.
| Original language | English |
|---|---|
| Pages (from-to) | 1329-1343 |
| Number of pages | 15 |
| Journal | International Journal of Polymeric Materials and Polymeric Biomaterials |
| Volume | 70 |
| Issue number | 18 |
| DOIs | |
| State | Published - 2021 |
Bibliographical note
Publisher Copyright:© 2020 Taylor & Francis Group, LLC.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Prodrug
- dasatinib
- hyaluronic acid
- redox-responsive
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