Reduced functional connectivity of somatosensory network in writer's cramp patients

Chia Hsiung Cheng*, Yi Jhan Tseng, Rou Shayn Chen, Yung Yang Lin

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

15 Scopus citations

Abstract

Background: The involvement of motor cortex and sensorimotor integration in patients with writer's cramp (WC) has been well documented. However, the exact neurophysiological profile within the somatosensory system, including primary somatosensory cortex (SI), contralateral (SIIc), and ipsilateral (SIIi) secondary somatosensory areas remains less understood. Methods: This study investigated the neuromagnetic cortical activities of median nerve stimulation in 10 patients with WC and 10 healthy controls (HC). To comprehensively explore all the aspects of somatosensory functioning, we analyzed our data with the minimum norm estimate (MNE), the time-frequency approach with evoked and induced activities, and functional connectivity between SI and SIIc (SI-SIIc), SI and SIIi (SI-SIIi), and SIIc and SIIi (SIIc-SIIi) from theta to gamma oscillations. Results: No significant between-group differences were found in the MNE cortical amplitudes of SI, SIIc, and SIIi. Power strengths of evoked gamma oscillation and induced beta synchronization were also equivalent between WC and HC groups. However, we found significantly reduced theta coherence of SI-SIIi, alpha coherence of SI-SIIi and SIIc-SIIi, as well as beta coherence of SIIc-SIIi in patients with WC. Conclusion: Our results suggest the involvement of somatosensory abnormalities, primarily with the form of functional connectivity, in patients with WC.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBrain and Behavior
Volume6
Issue number3
DOIs
StatePublished - 01 03 2016

Bibliographical note

Publisher Copyright:
© 2016 Published by Wiley Periodicals, Inc.

Keywords

  • Coherence
  • Dystonia
  • Magnetoencephalography (MEG)
  • Median nerve stimulation
  • Secondary somatosensory cortex (SII)

Fingerprint

Dive into the research topics of 'Reduced functional connectivity of somatosensory network in writer's cramp patients'. Together they form a unique fingerprint.

Cite this