Reduction of pro-inflammatory cytokines through hemodiafiltration

Huey Liang Kuo, Che Yi Chou, Yao Lung Liu, Ya Fei Yang, Chiu Ching Huang, Hsin Hung Lin*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

21 Scopus citations

Abstract

Background. Hemodialysis (HD) prolongs the life of the patients with end stage renal disease (ESRD), but the survival rates are still lower than the general population. More than half of ESRD patients died from cardiovascular disease (CVD). Recent studies have revealed that CVD is a consequence of vascular inflammation, and that there are active inflammatory processes in ESRD patients. Reports have indicated that ESRD patients have fewer CVD events and better survival with hemodiafiltration (HDF), but the reasons for this remain unclear. This study attempts to prove that HDF reduces the CVD-related cytokines. Methods. Seventeen adult HD outpatients were put on HDF in our hospital from September 2004 to June 2006. We collected plasma samples before and six months after initiation of HDF. The target pro-inflammatory cytokines selected were interleukin-6 (IL-6), interleukin-18 (IL-18), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP). Results. After six months of HDF, most of the biochemical parameters did not changed. Plasma IL-18 and TNF-α are decreased significantly (p < 0.05) but IL-6 and CRP are not. Conclusions. IL-18 and INF-α decreased significantly after six months of HDF. These cytokines are key factors in atherosclerotic plaque formation and rupture, and a reduction of these inflammatory cytokines in HDF may reduce the CVD incidence and prolong life.

Original languageEnglish
Pages (from-to)796-800
Number of pages5
JournalRenal Failure
Volume30
Issue number8
DOIs
StatePublished - 09 2008
Externally publishedYes

Keywords

  • C-reactive protein
  • Cardiovascular disease
  • Hemodiafiltration
  • Interleukin-18
  • Interleukin-6
  • Tumor necrosis factor-α

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