TY - JOUR
T1 - Regional difference in epidermal thinning after skin denervation
AU - Chiang, Hou Yu
AU - Huang, Ia Tang
AU - Chen, Wen Pin
AU - Chien, Hsiung Fei
AU - Shun, Chia Tung
AU - Chang, Ynag Chyuan
AU - Hsieh, Sung Tsang
PY - 1998/11
Y1 - 1998/11
N2 - Denervation of skin has a profound influence on epidermis; epidermal thinning was a consistent finding in rats. However, it is not clear whether the degree of epidermal thinning was similar in the region receiving the same innervation. In mice, how early epidermal nerves were degenerated after nerve injury remained unknown. To address these issues, we transected the sciatic nerve in mice and compared the changes of epidermal thickness in different areas of the hind foot skin. Epidermal nerves degenerated within 48 h after nerve transection, similar to what was observed in rats. Seven days after nerve transection, there was differential thinning of epidermis. The interpad area, in the center of the sciatic nerve-innervated region, exhibited the most profound degree of epidermal thinning (34.6 ± 3.1 vs 47.8 ± 2.4 μm, P < 0.01). The heel area, in the periphery of the sciatic nerve-innervated zone, did not show significant thinning of epidermis after denervation (37.3 ± 4.8 vs 41.5 ± 5.1 μm, P > 0.05). The degree of epidermal thinning after denervation in the pad area was the intermediate one: with 98.8 ± 4.8 vs 120.1 ± 7.3 μm, P < 0.02, in the fete pegs, and 51.1 ± 4.1 vs 62.1 ± 6.0 μm, P < 0.02, in the dermal papilla. The differential thinning was obvious when the thickness of the denervated epidermis was normalized to that of the control epidermis with the ratios of 0.73 ± 0.03 in the interpad area, 0.83 ± 0.04 in the rete peg, 0.85 ± 0.05 in the dermal papilla, and 0.92 ± 0.05 in the heel. Epidermal thinning was reversed by reinnervation of the epidermis after sciatic nerve crush (41.5 ± 1.5 vs 45.0 ± 2.0 μm in the interpad area, P > 0.05). These findings suggest that sensory nerves exhibit trophic influences on the epidermis presumably through the effects of diffusible factors.
AB - Denervation of skin has a profound influence on epidermis; epidermal thinning was a consistent finding in rats. However, it is not clear whether the degree of epidermal thinning was similar in the region receiving the same innervation. In mice, how early epidermal nerves were degenerated after nerve injury remained unknown. To address these issues, we transected the sciatic nerve in mice and compared the changes of epidermal thickness in different areas of the hind foot skin. Epidermal nerves degenerated within 48 h after nerve transection, similar to what was observed in rats. Seven days after nerve transection, there was differential thinning of epidermis. The interpad area, in the center of the sciatic nerve-innervated region, exhibited the most profound degree of epidermal thinning (34.6 ± 3.1 vs 47.8 ± 2.4 μm, P < 0.01). The heel area, in the periphery of the sciatic nerve-innervated zone, did not show significant thinning of epidermis after denervation (37.3 ± 4.8 vs 41.5 ± 5.1 μm, P > 0.05). The degree of epidermal thinning after denervation in the pad area was the intermediate one: with 98.8 ± 4.8 vs 120.1 ± 7.3 μm, P < 0.02, in the fete pegs, and 51.1 ± 4.1 vs 62.1 ± 6.0 μm, P < 0.02, in the dermal papilla. The differential thinning was obvious when the thickness of the denervated epidermis was normalized to that of the control epidermis with the ratios of 0.73 ± 0.03 in the interpad area, 0.83 ± 0.04 in the rete peg, 0.85 ± 0.05 in the dermal papilla, and 0.92 ± 0.05 in the heel. Epidermal thinning was reversed by reinnervation of the epidermis after sciatic nerve crush (41.5 ± 1.5 vs 45.0 ± 2.0 μm in the interpad area, P > 0.05). These findings suggest that sensory nerves exhibit trophic influences on the epidermis presumably through the effects of diffusible factors.
KW - Axonal degeneration
KW - Epidermis
KW - Keratinocyte
KW - Nerve degeneration
KW - Protein gene product 9.5
KW - Skin innervation
KW - Unmyelinated nerves
UR - http://www.scopus.com/inward/record.url?scp=0032213460&partnerID=8YFLogxK
U2 - 10.1006/exnr.1998.6896
DO - 10.1006/exnr.1998.6896
M3 - 文章
C2 - 9875275
AN - SCOPUS:0032213460
SN - 0014-4886
VL - 154
SP - 137
EP - 145
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -