Regressed subungual melanoma simulating cellular blue nevus: Managed with sentinel lymph node biopsy

Chih Hsun Yang; Jiun Ting Yeh; Su Chin Shen; Yung Feng Lo; Tseng Tong Kuo; John W.C. Chang

doi:10.1111/j.1524-4725.2006.32119.x

Regressed subungual melanoma simulating cellular blue nevus: Managed with sentinel lymph node biopsy

Chih Hsun Yang, Jiun Ting Yeh, Su Chin Shen, Yung Feng Lo, Tseng Tong Kuo, John W.C. Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

BACKGROUND: Subungual melanoma, a not uncommon presentation of cutaneous melanoma in Asian populations, is easily overlooked as benign and thus is improperly treated. OBJECTIVE: To present two cases with clinical suspicion of subungual melanoma. Skin biopsies failed to demonstrate the diagnostic features of malignacy. METHODS: Lymphoscintigraphy and sentinel lymph node (SLN) biopsies were performed to determine regional lymph node status. RESULTS: Both hematoxylin-eosin and HMB45 staining revealed melanoma cells in the SLN of the patient. The second patient's SLN was negative for malignant cells, but her excised primary lesion showed extensive regressed melanoma. CONCLUSION: Regression phenomena are not uncommon for subungual melanoma. An extention biopsy techniques are useful for determining nodal basin status in regressed subungal melanoma.

Original language	English
Pages (from-to)	577-581
Number of pages	5
Journal	Dermatologic Surgery
Volume	32
Issue number	4
DOIs	https://doi.org/10.1111/j.1524-4725.2006.32119.x
State	Published - 04 2006
Externally published	Yes

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10.1111/j.1524-4725.2006.32119.x

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title = "Regressed subungual melanoma simulating cellular blue nevus: Managed with sentinel lymph node biopsy",

abstract = "BACKGROUND: Subungual melanoma, a not uncommon presentation of cutaneous melanoma in Asian populations, is easily overlooked as benign and thus is improperly treated. OBJECTIVE: To present two cases with clinical suspicion of subungual melanoma. Skin biopsies failed to demonstrate the diagnostic features of malignacy. METHODS: Lymphoscintigraphy and sentinel lymph node (SLN) biopsies were performed to determine regional lymph node status. RESULTS: Both hematoxylin-eosin and HMB45 staining revealed melanoma cells in the SLN of the patient. The second patient's SLN was negative for malignant cells, but her excised primary lesion showed extensive regressed melanoma. CONCLUSION: Regression phenomena are not uncommon for subungual melanoma. An extention biopsy techniques are useful for determining nodal basin status in regressed subungal melanoma.",

author = "Yang, {Chih Hsun} and Yeh, {Jiun Ting} and Shen, {Su Chin} and Lo, {Yung Feng} and Kuo, {Tseng Tong} and Chang, {John W.C.}",

year = "2006",

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doi = "10.1111/j.1524-4725.2006.32119.x",

language = "英语",

volume = "32",

pages = "577--581",

journal = "Dermatologic Surgery",

issn = "1076-0512",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Regressed subungual melanoma simulating cellular blue nevus

T2 - Managed with sentinel lymph node biopsy

AU - Yang, Chih Hsun

AU - Yeh, Jiun Ting

AU - Shen, Su Chin

AU - Lo, Yung Feng

AU - Kuo, Tseng Tong

AU - Chang, John W.C.

PY - 2006/4

Y1 - 2006/4

N2 - BACKGROUND: Subungual melanoma, a not uncommon presentation of cutaneous melanoma in Asian populations, is easily overlooked as benign and thus is improperly treated. OBJECTIVE: To present two cases with clinical suspicion of subungual melanoma. Skin biopsies failed to demonstrate the diagnostic features of malignacy. METHODS: Lymphoscintigraphy and sentinel lymph node (SLN) biopsies were performed to determine regional lymph node status. RESULTS: Both hematoxylin-eosin and HMB45 staining revealed melanoma cells in the SLN of the patient. The second patient's SLN was negative for malignant cells, but her excised primary lesion showed extensive regressed melanoma. CONCLUSION: Regression phenomena are not uncommon for subungual melanoma. An extention biopsy techniques are useful for determining nodal basin status in regressed subungal melanoma.

AB - BACKGROUND: Subungual melanoma, a not uncommon presentation of cutaneous melanoma in Asian populations, is easily overlooked as benign and thus is improperly treated. OBJECTIVE: To present two cases with clinical suspicion of subungual melanoma. Skin biopsies failed to demonstrate the diagnostic features of malignacy. METHODS: Lymphoscintigraphy and sentinel lymph node (SLN) biopsies were performed to determine regional lymph node status. RESULTS: Both hematoxylin-eosin and HMB45 staining revealed melanoma cells in the SLN of the patient. The second patient's SLN was negative for malignant cells, but her excised primary lesion showed extensive regressed melanoma. CONCLUSION: Regression phenomena are not uncommon for subungual melanoma. An extention biopsy techniques are useful for determining nodal basin status in regressed subungal melanoma.

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DO - 10.1111/j.1524-4725.2006.32119.x

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Regressed subungual melanoma simulating cellular blue nevus: Managed with sentinel lymph node biopsy

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