Regulation of stress granule dynamics by Grb7 and FAK signalling pathway

Nien Pei Tsai, Ping Chih Ho, Li Na Wei*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

72 Scopus citations


Cells form stress granules (SGs) in response to environmental stresses, which constitute cytoplasmic domains where mRNAs are stored and translation is halted. Although several components are found in SGs, it is poorly understood as to how SGs are formed and dissolved. We identified growth factor receptor-bound protein 7 (Grb7), an RNA-binding, translational regulator, as an integral component of SGs, which directly interacts with Hu antigen R (HuR) and is required for cells to form SGs. When stress is terminated, Grb7 is hyperphosphorylated by focal adhesion kinase (FAK), loses its ability to directly interact with HuR and is dissociated from SG components, thereby disrupting SGs in recovering cells. Consistently, dominant-negative hypophospho mutants of FAK and Grb7 significantly attenuate SG disassembly during recovery. FAK activation followed by its phosphorylating Grb7 constitutes a cell-autonomous signalling pathway that regulates the disassembly of SGs and translational stimulation during recovery. This is the first reported pathway actively regulating the dynamics of SGs.

Original languageEnglish
Pages (from-to)715-726
Number of pages12
JournalEMBO Journal
Issue number5
StatePublished - 05 03 2008
Externally publishedYes


  • FAK
  • Grb7
  • Stress granules


Dive into the research topics of 'Regulation of stress granule dynamics by Grb7 and FAK signalling pathway'. Together they form a unique fingerprint.

Cite this