Regulation of the transcription of G protein-coupled receptor genes

Cheol Kyu Hwang*, Ping Yee Law, Li Na Wei, Horace H. Loh

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


G protein-coupled receptors (GPCRs) participate in a variety of physiological functions and are major targets of pharmaceutical drugs. More than 600 GPCRs have been identified in the human genome. Although GPCRs are expressed in multiple tissues and individual tissues express multiple GPCRs, many have exclusive or increased expression within the central nervous system (CNS). These unique and diverse expression patterns raise fundamental questions as to the molecular mechanisms underlying the tissue/cell-specific distribution of GPCRs as well as the means by which their expression is altered in response to stimuli. Gene expression in mammals involves both transcriptional and posttranscriptional mechanisms. In this chapter, we provide an overview of the transcriptional regulation of GPCRs and discuss both established and emerging techniques to study transcriptional regulation.

Original languageEnglish
Title of host publicationMethods for the Discovery and Characterization of G Protein-Coupled Receptors
EditorsCraig W. Stevens
Number of pages21
StatePublished - 2011

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • ChIP-on-chip
  • Chromatin immunoprecipitation
  • Electrophoretic mobility shift assay
  • Epigenetic
  • G protein-coupled receptor
  • Gene expression
  • Histone


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