Abstract
Reinvestigation the synthesis of quinolones from ortho-amidoacetophenones by trimethylsilyl trifluoromethanesulfonate (TMSOTf) mediated reaction is reported. In addition to receiving the expected quinolones, an unexpected intermolecular self-condensation adduct was also isolated. The detailed mechanism of its formation is discussed.
Original language | English |
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Pages (from-to) | 2006-2011 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 72 |
Issue number | 16 |
DOIs | |
State | Published - 21 04 2016 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Ltd.
Keywords
- Lewis-acid-assisted and Brønsted-acid-catalyzed reaction
- Methylquinoline
- Quinolone
- Trifluoromethanesulfonic acid
- Trimethylsilyl trifluoromethanesulfonate