Relationship between polymorphisms of nucleotide excision repair genes and oral cancer risk in Taiwan: Evidence for modification of smoking habit

Da Tian Bau, Ming Hsui Tsai, Chih Yang Huang, Cheng Chun Lee, Hsien Chang Tseng, Yen Li Lo, Yuhsin Tsai, Fuu Jen Tsai*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

48 Scopus citations

Abstract

Inherited polymorphisms in DNA repair genes may be associated with differences in the repair capacity and contribute to individual's susceptibility to smoking-related cancers. Both XPA and XPD encode proteins that are part of the nucleotide excision repair (NER) pathway. In a hospital-based casecontrol study, we have investigated the influence of XPA A-23G and XPD Lys751Gln polymorphisms on oral cancer risk in a Taiwanese population. In total, 154 patients with oral cancer, and 105 age-matched controls recruited from the Chinese Medical Hospital in Central Taiwan were genotyped. No significant association was found between the heterozygous variant allele (AG), the homozygous variant allele (AA) at XPA A-23G, the heterozygous variant allele (AC), the homozygous variant allele (CC) at XPD Lys751Gln, and oral cancer risk. There was no significant joint effect of XPA A-23G and XPD Lys751Gln on oral cancer risk either. Since XPA and XPD are both NER genes, which are very important in removing tobacco-induced DNA adducts, further stratified analyses of both genotype and smoking habit were performed. We found a synergistic effect of variant genotypes of both XPA and XPD, and smoking status on oral cancer risk. Our results suggest that the genetic polymorphisms are modified by environmental carcinogen exposure status, and combined analyses of both genotype and personal habit record are a better access to know the development of oral cancer and useful for primary prevention and early intervention.

Original languageEnglish
Pages (from-to)294-300
Number of pages7
JournalChinese Journal of Physiology
Volume50
Issue number6
StatePublished - 2007
Externally publishedYes

Keywords

  • Nucleotide excision repair
  • Oral cancer
  • Polymorphism
  • XPA
  • XPD

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