Relative covid-19 viral persistence and antibody kinetics

Chung Guei Huang; Avijit Dutta; Ching Tai Huang; Pi Yueh Chang; Mei Jen Hsiao; Yu Chia Hsieh; Shu Min Lin; Shin Ru Shih; Kuo Chien Tsao; Cheng Ta Yang

doi:10.3390/pathogens10060752

Relative covid-19 viral persistence and antibody kinetics

Chung Guei Huang, Avijit Dutta, Ching Tai Huang, Pi Yueh Chang, Mei Jen Hsiao, Yu Chia Hsieh, Shu Min Lin, Shin Ru Shih, Kuo Chien Tsao, Cheng Ta Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

A total of 15 RT-PCR confirmed COVID-19 patients were admitted to our hospital during the in-itial outbreak in Taiwan. The average time of virus clearance was delayed in seven patients, 24.14 ± 4.33 days compared to 10.25 ± 0.56 days post-symptom onset (PSO) in the other eight pa-tients. There was strong antibody response in patients with viral persistence at the pharynx, with peak values of serum antibody 677.2 ± 217.8 vs. 76.70 ± 32.11 in patients with delayed versus rapid virus clearance. The patients with delayed viral clearance had excessive antibodies of compromised quality in an early stage with the delay in peak virus neutralization efficacy, 34.14 ± 7.15 versus 12.50 ± 2.35 days PSO in patients with rapid virus clearance. Weak antibody re-sponse of patients with rapid viral clearance was also effective, with substantial and comparable neutralization efficacy, 35.70 ± 8.78 versus 41.37 ± 11.49 of patients with delayed virus clearance. Human Cytokine 48-Plex Screening of the serial sera samples revealed elevated concentrations of proinflammatory cytokines and chemokines in a deceased patient with delayed virus clear-ance and severe disease. The levels were comparatively less in the other two patients who suf-fered from severe disease but eventually survived.

Original language	English
Article number	752
Journal	Pathogens
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/pathogens10060752
State	Published - 06 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

COVID-19
Cytokine profile
Neutralization efficacy
Serum antibody
Viral persistence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pathogens10060752

Cite this

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title = "Relative covid-19 viral persistence and antibody kinetics",

abstract = "A total of 15 RT-PCR confirmed COVID-19 patients were admitted to our hospital during the in-itial outbreak in Taiwan. The average time of virus clearance was delayed in seven patients, 24.14 ± 4.33 days compared to 10.25 ± 0.56 days post-symptom onset (PSO) in the other eight pa-tients. There was strong antibody response in patients with viral persistence at the pharynx, with peak values of serum antibody 677.2 ± 217.8 vs. 76.70 ± 32.11 in patients with delayed versus rapid virus clearance. The patients with delayed viral clearance had excessive antibodies of compromised quality in an early stage with the delay in peak virus neutralization efficacy, 34.14 ± 7.15 versus 12.50 ± 2.35 days PSO in patients with rapid virus clearance. Weak antibody re-sponse of patients with rapid viral clearance was also effective, with substantial and comparable neutralization efficacy, 35.70 ± 8.78 versus 41.37 ± 11.49 of patients with delayed virus clearance. Human Cytokine 48-Plex Screening of the serial sera samples revealed elevated concentrations of proinflammatory cytokines and chemokines in a deceased patient with delayed virus clear-ance and severe disease. The levels were comparatively less in the other two patients who suf-fered from severe disease but eventually survived.",

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author = "Huang, {Chung Guei} and Avijit Dutta and Huang, {Ching Tai} and Chang, {Pi Yueh} and Hsiao, {Mei Jen} and Hsieh, {Yu Chia} and Lin, {Shu Min} and Shih, {Shin Ru} and Tsao, {Kuo Chien} and Yang, {Cheng Ta}",

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doi = "10.3390/pathogens10060752",

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AU - Dutta, Avijit

AU - Huang, Ching Tai

AU - Chang, Pi Yueh

AU - Hsiao, Mei Jen

AU - Hsieh, Yu Chia

AU - Lin, Shu Min

AU - Shih, Shin Ru

AU - Tsao, Kuo Chien

AU - Yang, Cheng Ta

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AB - A total of 15 RT-PCR confirmed COVID-19 patients were admitted to our hospital during the in-itial outbreak in Taiwan. The average time of virus clearance was delayed in seven patients, 24.14 ± 4.33 days compared to 10.25 ± 0.56 days post-symptom onset (PSO) in the other eight pa-tients. There was strong antibody response in patients with viral persistence at the pharynx, with peak values of serum antibody 677.2 ± 217.8 vs. 76.70 ± 32.11 in patients with delayed versus rapid virus clearance. The patients with delayed viral clearance had excessive antibodies of compromised quality in an early stage with the delay in peak virus neutralization efficacy, 34.14 ± 7.15 versus 12.50 ± 2.35 days PSO in patients with rapid virus clearance. Weak antibody re-sponse of patients with rapid viral clearance was also effective, with substantial and comparable neutralization efficacy, 35.70 ± 8.78 versus 41.37 ± 11.49 of patients with delayed virus clearance. Human Cytokine 48-Plex Screening of the serial sera samples revealed elevated concentrations of proinflammatory cytokines and chemokines in a deceased patient with delayed virus clear-ance and severe disease. The levels were comparatively less in the other two patients who suf-fered from severe disease but eventually survived.

KW - COVID-19

KW - Cytokine profile

KW - Neutralization efficacy

KW - Serum antibody

KW - Viral persistence

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Relative covid-19 viral persistence and antibody kinetics

Abstract

Bibliographical note

Keywords

UN SDGs

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