Abstract
Background: The association between renal function and ejection fraction in predicting mortality in patients with reduced systolic function is unclear. Methods: This cohort study analyzed 801 patients with left ventricular ejection fraction (LVEF) ≤ 35%. The LVEF was categorized as 20-35% for non-chronic kidney disease (CKD) group versus ≤ 20% for the CKD group. The Cox proportional hazard model and multivariable-adjusted risk determined relationships among LVEF, eGFR, and mortality. Results: The cumulative survival rate was associated with a combined effect of CKD and LVEF levels. The hazard ratios (with corresponding 95% CIs) for the combined effect were 2.953 (95% CI = 2.167-4.024) for the CKD group with LVEF = 20-35% and 2.661 (95% CI = 1.728-4.098) for the CKD group with LVEF ≤ 20%. The hazard ratio was 1.994 (95% CI =1.195-3.328) for the non-CKD group with LVEF ≤ 20% as compared with those in the non-CKD group with LVEF = 20-35%. All P-values were < 0.05. Conclusions: The combination of CKD and LVEF is a strong predictor of mortality in patients with systolic heart failure.
| Original language | English |
|---|---|
| Pages (from-to) | 2862-2889 |
| Number of pages | 28 |
| Journal | Experimental and Clinical Cardiology |
| Volume | 20 |
| Issue number | 1 |
| State | Published - 2014 |
| Externally published | Yes |
Keywords
- Chronic kidney disease
- Left ventricular ejection fraction
- Reduced systolic function
- Renal disease
- Systolic heart failure
