TY - JOUR
T1 - Respiration-averaged CT for attenuation correction in non-small-cell lung cancer
AU - Cheng, Nai Ming
AU - Yu, Chih Teng
AU - Ho, Kung Chu
AU - Wu, Yi Cheng
AU - Liu, Yuan Chang
AU - Wang, Chih Wei
AU - Yen, Tzu Chen
PY - 2009/4
Y1 - 2009/4
N2 - Purpose: Breathing causes artefacts on PET/CT images. Cine CT has been used to reduce respiratory artefacts by acquiring multiple images during a single breathing cycle. The aim of this prospective study in non-small-cell lung cancer (NSCLC) patients was twofold. Firstly, we sought to compare the motion artefacts in PET/CT images attenuation-corrected with helical CT (HCT) and with averaged CT (ACT), which provides an average of cine CT images. Secondly, we wanted to evaluate the differences in maximum standardized uptake values (SUVmax) between HCT and ACT. Methods: Enrolled in the study were 80 patients with NSCLC. PET images attenuation-corrected with HCT (PET/HCT) and with ACT (PET/ACT) were obtained in all patients. Misregistration was evaluated by measurement of the curved photopenic area in the lower thorax of the PET images for all patients and direct measurement of misregistration for selected lesions. SUVmax was measured separately at the primary tumours, regional lymph nodes, and background. Results: A total of 80 patients with NSCLC were included. Significantly lower misregistrations were observed in PET/ACT images than in PET/HCT images (below-thoracic misregistration 0.25±0.58 cm vs. 1.17±1.17 cm, p<0.001; lesion misregistration 1.38±2.10 vs. 3.10±4.09, p=0.013). Significantly higher SUVmax were noted in PET/ACT images than in PET/HCT images in the primary tumour (p<0.001) and regional lymph nodes (p<0.001). Compared with PET/HCT images, the magnitude of SUVmax in PET/ACT images was higher by 0.35 for the main tumours and 0.34 for lymph nodes. Conclusion: Due to its significantly reduced misregistration, PET/ACT provided more reliable SUV max and may be useful in treatment planning and monitoring the therapeutic response in patients with NSCLC.
AB - Purpose: Breathing causes artefacts on PET/CT images. Cine CT has been used to reduce respiratory artefacts by acquiring multiple images during a single breathing cycle. The aim of this prospective study in non-small-cell lung cancer (NSCLC) patients was twofold. Firstly, we sought to compare the motion artefacts in PET/CT images attenuation-corrected with helical CT (HCT) and with averaged CT (ACT), which provides an average of cine CT images. Secondly, we wanted to evaluate the differences in maximum standardized uptake values (SUVmax) between HCT and ACT. Methods: Enrolled in the study were 80 patients with NSCLC. PET images attenuation-corrected with HCT (PET/HCT) and with ACT (PET/ACT) were obtained in all patients. Misregistration was evaluated by measurement of the curved photopenic area in the lower thorax of the PET images for all patients and direct measurement of misregistration for selected lesions. SUVmax was measured separately at the primary tumours, regional lymph nodes, and background. Results: A total of 80 patients with NSCLC were included. Significantly lower misregistrations were observed in PET/ACT images than in PET/HCT images (below-thoracic misregistration 0.25±0.58 cm vs. 1.17±1.17 cm, p<0.001; lesion misregistration 1.38±2.10 vs. 3.10±4.09, p=0.013). Significantly higher SUVmax were noted in PET/ACT images than in PET/HCT images in the primary tumour (p<0.001) and regional lymph nodes (p<0.001). Compared with PET/HCT images, the magnitude of SUVmax in PET/ACT images was higher by 0.35 for the main tumours and 0.34 for lymph nodes. Conclusion: Due to its significantly reduced misregistration, PET/ACT provided more reliable SUV max and may be useful in treatment planning and monitoring the therapeutic response in patients with NSCLC.
KW - Attenuation correction
KW - Averaged CT
KW - Misregistration
KW - Non-small-cell lung cancer
KW - Standardized uptake value
UR - https://www.scopus.com/pages/publications/62149093969
U2 - 10.1007/s00259-008-0995-7
DO - 10.1007/s00259-008-0995-7
M3 - 文章
C2 - 19050875
AN - SCOPUS:62149093969
SN - 1619-7070
VL - 36
SP - 607
EP - 615
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
IS - 4
ER -
