Respiratory Muscle Training Improves Functional Outcomes and Reduces Fatigue in Patients with Myasthenia Gravis: A Single-Center Hospital-Based Prospective Study

Che Wei Hsu; Hui Chen Lin; Wan Chen Tsai; Yun Ru Lai; Chih Cheng Huang; Yu Jih Su; Ben Chung Cheng; Mao Chang Su; Wei Che Lin; Chia Ling Chang; Wen Neng Chang; Meng Chih Lin; Cheng Hsien Lu; Nai Wen Tsai; Mario Bernardo-Filho

doi:10.1155/2020/2923907

Respiratory Muscle Training Improves Functional Outcomes and Reduces Fatigue in Patients with Myasthenia Gravis: A Single-Center Hospital-Based Prospective Study

Che Wei Hsu, Hui Chen Lin, Wan Chen Tsai, Yun Ru Lai, Chih Cheng Huang, Yu Jih Su, Ben Chung Cheng, Mao Chang Su, Wei Che Lin, Chia Ling Chang, Wen Neng Chang, Meng Chih Lin, Cheng Hsien Lu, Nai Wen Tsai^*, Mario Bernardo-Filho

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

Background. Myasthenia gravis (MG) is an immune-mediated disorder characterized by muscle fatigue and fluctuating weakness. Impairment in respiratory strength and endurance has been described in patients with generalized MG. We tested the hypothesis that respiratory muscle training (RMT) can improve functional outcomes and reduce fatigue in patients with MG. Methods. Eighteen patients with mild to moderate MG participated in this study. The training group underwent home-based RMT three times a week for 12 weeks. Sixteen patients with MG without RMT were enrolled as a disease control group. Lung function, autonomic testing, Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), and functional outcome measurement by using quantitative myasthenia gravis (QMG) score and myasthenia gravis composite (MGC) scale were measured before and after the 12-week RMT. Results. The 12-week RMT significantly increased forced vital capacity (FVC) from 77.9±12.6% to 83.8±17.7% (p=0.03), forced expiratory volume in one second (FEV1) from 75.2±18.3% to 83.3±19.0% (p=0.002), and 6-minute walking distance from 403.4±72.2 m to 466.1±68.5 m (p=0.003). The QMG score improved from 9.6±4.1 to 8.1±4.3 (p=0.04) and the MGC scale from 4.4±3.5 to 2.7±2.9 (p=0.02). The fatigue score (MFSI-SF) reduced from 17.1±14.7 to 13.5±16.9 (p=0.03). Conclusion. The home-based RMT is an effective pulmonary function training for MG patients. The RMT can not only improve short-term outcomes but also reduce fatigue in patients with mild to moderate generalized MG.

Original language	English
Article number	2923907
Journal	BioMed Research International
Volume	2020
DOIs	https://doi.org/10.1155/2020/2923907
State	Published - 2020

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© 2020 Che-Wei Hsu et al.

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Hsu, C. W., Lin, H. C., Tsai, W. C., Lai, Y. R., Huang, C. C., Su, Y. J., Cheng, B. C., Su, M. C., Lin, W. C., Chang, C. L., Chang, W. N., Lin, M. C., Lu, C. H., Tsai, N. W., & Bernardo-Filho, M. (2020). Respiratory Muscle Training Improves Functional Outcomes and Reduces Fatigue in Patients with Myasthenia Gravis: A Single-Center Hospital-Based Prospective Study. BioMed Research International, 2020, Article 2923907. https://doi.org/10.1155/2020/2923907

@article{de9a928c79e841a384c1c80c10bd7197,

title = "Respiratory Muscle Training Improves Functional Outcomes and Reduces Fatigue in Patients with Myasthenia Gravis: A Single-Center Hospital-Based Prospective Study",

abstract = "Background. Myasthenia gravis (MG) is an immune-mediated disorder characterized by muscle fatigue and fluctuating weakness. Impairment in respiratory strength and endurance has been described in patients with generalized MG. We tested the hypothesis that respiratory muscle training (RMT) can improve functional outcomes and reduce fatigue in patients with MG. Methods. Eighteen patients with mild to moderate MG participated in this study. The training group underwent home-based RMT three times a week for 12 weeks. Sixteen patients with MG without RMT were enrolled as a disease control group. Lung function, autonomic testing, Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), and functional outcome measurement by using quantitative myasthenia gravis (QMG) score and myasthenia gravis composite (MGC) scale were measured before and after the 12-week RMT. Results. The 12-week RMT significantly increased forced vital capacity (FVC) from 77.9±12.6% to 83.8±17.7% (p=0.03), forced expiratory volume in one second (FEV1) from 75.2±18.3% to 83.3±19.0% (p=0.002), and 6-minute walking distance from 403.4±72.2 m to 466.1±68.5 m (p=0.003). The QMG score improved from 9.6±4.1 to 8.1±4.3 (p=0.04) and the MGC scale from 4.4±3.5 to 2.7±2.9 (p=0.02). The fatigue score (MFSI-SF) reduced from 17.1±14.7 to 13.5±16.9 (p=0.03). Conclusion. The home-based RMT is an effective pulmonary function training for MG patients. The RMT can not only improve short-term outcomes but also reduce fatigue in patients with mild to moderate generalized MG.",

author = "Hsu, {Che Wei} and Lin, {Hui Chen} and Tsai, {Wan Chen} and Lai, {Yun Ru} and Huang, {Chih Cheng} and Su, {Yu Jih} and Cheng, {Ben Chung} and Su, {Mao Chang} and Lin, {Wei Che} and Chang, {Chia Ling} and Chang, {Wen Neng} and Lin, {Meng Chih} and Lu, {Cheng Hsien} and Tsai, {Nai Wen} and Mario Bernardo-Filho",

note = "Publisher Copyright: {\textcopyright} 2020 Che-Wei Hsu et al.",

year = "2020",

doi = "10.1155/2020/2923907",

language = "英语",

volume = "2020",

journal = "BioMed Research International",

issn = "2314-6133",

publisher = "John Wiley and Sons Ltd",

}

Hsu, CW, Lin, HC, Tsai, WC, Lai, YR, Huang, CC, Su, YJ, Cheng, BC, Su, MC, Lin, WC, Chang, CL, Chang, WN, Lin, MC, Lu, CH, Tsai, NW & Bernardo-Filho, M 2020, 'Respiratory Muscle Training Improves Functional Outcomes and Reduces Fatigue in Patients with Myasthenia Gravis: A Single-Center Hospital-Based Prospective Study', BioMed Research International, vol. 2020, 2923907. https://doi.org/10.1155/2020/2923907

TY - JOUR

T1 - Respiratory Muscle Training Improves Functional Outcomes and Reduces Fatigue in Patients with Myasthenia Gravis

T2 - A Single-Center Hospital-Based Prospective Study

AU - Hsu, Che Wei

AU - Lin, Hui Chen

AU - Tsai, Wan Chen

AU - Lai, Yun Ru

AU - Huang, Chih Cheng

AU - Su, Yu Jih

AU - Cheng, Ben Chung

AU - Su, Mao Chang

AU - Lin, Wei Che

AU - Chang, Chia Ling

AU - Chang, Wen Neng

AU - Lin, Meng Chih

AU - Lu, Cheng Hsien

AU - Tsai, Nai Wen

AU - Bernardo-Filho, Mario

PY - 2020

Y1 - 2020

N2 - Background. Myasthenia gravis (MG) is an immune-mediated disorder characterized by muscle fatigue and fluctuating weakness. Impairment in respiratory strength and endurance has been described in patients with generalized MG. We tested the hypothesis that respiratory muscle training (RMT) can improve functional outcomes and reduce fatigue in patients with MG. Methods. Eighteen patients with mild to moderate MG participated in this study. The training group underwent home-based RMT three times a week for 12 weeks. Sixteen patients with MG without RMT were enrolled as a disease control group. Lung function, autonomic testing, Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), and functional outcome measurement by using quantitative myasthenia gravis (QMG) score and myasthenia gravis composite (MGC) scale were measured before and after the 12-week RMT. Results. The 12-week RMT significantly increased forced vital capacity (FVC) from 77.9±12.6% to 83.8±17.7% (p=0.03), forced expiratory volume in one second (FEV1) from 75.2±18.3% to 83.3±19.0% (p=0.002), and 6-minute walking distance from 403.4±72.2 m to 466.1±68.5 m (p=0.003). The QMG score improved from 9.6±4.1 to 8.1±4.3 (p=0.04) and the MGC scale from 4.4±3.5 to 2.7±2.9 (p=0.02). The fatigue score (MFSI-SF) reduced from 17.1±14.7 to 13.5±16.9 (p=0.03). Conclusion. The home-based RMT is an effective pulmonary function training for MG patients. The RMT can not only improve short-term outcomes but also reduce fatigue in patients with mild to moderate generalized MG.

AB - Background. Myasthenia gravis (MG) is an immune-mediated disorder characterized by muscle fatigue and fluctuating weakness. Impairment in respiratory strength and endurance has been described in patients with generalized MG. We tested the hypothesis that respiratory muscle training (RMT) can improve functional outcomes and reduce fatigue in patients with MG. Methods. Eighteen patients with mild to moderate MG participated in this study. The training group underwent home-based RMT three times a week for 12 weeks. Sixteen patients with MG without RMT were enrolled as a disease control group. Lung function, autonomic testing, Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), and functional outcome measurement by using quantitative myasthenia gravis (QMG) score and myasthenia gravis composite (MGC) scale were measured before and after the 12-week RMT. Results. The 12-week RMT significantly increased forced vital capacity (FVC) from 77.9±12.6% to 83.8±17.7% (p=0.03), forced expiratory volume in one second (FEV1) from 75.2±18.3% to 83.3±19.0% (p=0.002), and 6-minute walking distance from 403.4±72.2 m to 466.1±68.5 m (p=0.003). The QMG score improved from 9.6±4.1 to 8.1±4.3 (p=0.04) and the MGC scale from 4.4±3.5 to 2.7±2.9 (p=0.02). The fatigue score (MFSI-SF) reduced from 17.1±14.7 to 13.5±16.9 (p=0.03). Conclusion. The home-based RMT is an effective pulmonary function training for MG patients. The RMT can not only improve short-term outcomes but also reduce fatigue in patients with mild to moderate generalized MG.

UR - http://www.scopus.com/inward/record.url?scp=85082938977&partnerID=8YFLogxK

U2 - 10.1155/2020/2923907

DO - 10.1155/2020/2923907

M3 - 文章

C2 - 32280685

AN - SCOPUS:85082938977

SN - 2314-6133

VL - 2020

JO - BioMed Research International

JF - BioMed Research International

M1 - 2923907

ER -

Respiratory Muscle Training Improves Functional Outcomes and Reduces Fatigue in Patients with Myasthenia Gravis: A Single-Center Hospital-Based Prospective Study

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