Response to influenza vaccine in children with leukemia undergoing chemotherapy

Yu Chia Hsieh, Meng Yao Lu, Chuan Laing Kao, Bor Luen Chian, Dong Tasmn Lin, Kai Sin Lin, Li Min Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

29 Scopus citations


Background and Purpose: To assess the ability of children with acute lymphoblastic leukemia (ALL) to develop an antibody response after influenza vaccination. Method: A total of 65 children under 15 years old were studied, including 25 children with ALL undergoing chemotheraphy, 30 with asthma in remission who were regularly followed at clinics, and 10 healthy children. The influenza vaccine contained antigens B/Yamanashi/166/98, A/New caledonia/20/99/(H1N1), and A/Panama/2007/99(H3N2). Results: Children with ALL developed significant antibody titers to A/Panama/2007/99 antigen 4 weeks after the second immunization. Seroconversion rates after two doses of vaccine were 57.1 to 84.6% and seroresponse rates were between 24 and 60% in children with ALL. Compared to children with asthma in remission, who were regarded as immunocompetent individuals, the ALL children had less seroconversion and lower seroresponse rates to B/Yamanashi/166.98 and A/ Panama/2007/99(H3N2) antigens were comparable in asthmatic and leukemic children. On the other hand, the antibody response in children with ALL who received reinduction chemotherapy suggest that the therapy did not impair seroresponse rates. Conclusion: Our data suggest that the influenza vaccine is safe and effective in children with either ALL or asthma in Taiwan.

Original languageEnglish
Pages (from-to)700-704
Number of pages5
JournalJournal of the Formosan Medical Association
Issue number10
StatePublished - 01 10 2002
Externally publishedYes


  • Acute lymphoblastic leukemia
  • Asthma
  • Children
  • Influenza vaccine


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