Restoration of asymmetric dimethylarginine-nitric oxide balance to prevent the development of hypertension

You Lin Tain, Li Tung Huang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

Despite the use of extensive antihypertensive therapy in patients with hypertension, little attention has been paid to early identification and intervention of individuals at risk for developing hypertension. The imbalance between nitric oxide (NO) and reactive oxygen species (ROS) resulting in oxidative stress has been implicated in the pathophysiology of hypertension. NO deficiency can precede the development of hypertension. Asymmetric dimethylarginine (ADMA) can inhibit nitric oxide synthase (NOS) and regulate local NO/ROS balance. Emerging evidence supports the hypothesis that ADMA-induced NO-ROS imbalance is involved in the development and progression of hypertension. Thus, this review summarizes recent experimental approaches to restore ADMA-NO balance in order to prevent the development of hypertension. Since hypertension might originate in early life, we also discuss the putative role of the ADMA-NO pathway in programmed hypertension. Better understanding of manipulations of the ADMA-NO pathway prior to hypertension in favor of NO will pave the way for the development of more effective medicine for the treatment prehypertension and programmed hypertension. However, more studies are needed to confirm the clinical benefit of these interventions.

Original languageEnglish
Pages (from-to)11773-11782
Number of pages10
JournalInternational Journal of Molecular Sciences
Volume15
Issue number7
DOIs
StatePublished - 02 07 2014

Keywords

  • Asymmetric dimethylarginine
  • Hypertension
  • Nitric oxide
  • Prehypertension
  • Programmed hypertension

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