Resveratrol ameliorates vasculopathy in STZ-induced diabetic rats: Role of AGE-RAGE signalling

Yu Hong Jing, Kuan Hsing Chen, Shu Han Yang, Pei Ching Kuo, Jan Kan Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

54 Scopus citations


Background: Resveratrol (RSV) has been shown to ameliorate hyperglycaemia and hyperlipidaemia in streptozotocin-induced diabetic rats. In the present study, we examined the beneficial effects of RSV on diabetes mellitus (DM)-induced vasculopathy and explored its possible mechanism. Methods: Male Sprague-Dawley rats were injected with streptozotocin at 65 mg/kg bodyweight The induction of DMwas confirmed by a fasting plasma glucose level ≥300 mg/dL and symptoms of polyphagia and polydipsia. The DM rats were treated with or without RSV at 0.75 mg/kg body weight three times a day for 4-8 weeks. Animals were sacrificed and vessel wall histology was examined by microscopy. The vascular smooth muscle cell activation was assessed by the medial thickness, collagen deposition, and the expressions receptor for advanced glycation end product, NF-κB, proliferation cell nuclear antigen, and the levels of Erk1/2 phosphorylation. Results: In RSV-treated DM rats, the vascular wall thickening, collagen deposition/cross-linking, and vascular permeability were all alleviated compared with that of the untreated DM rats. The vascular smooth muscle cell of the RSV-treated rats was characterized with less proliferation, lower NF-κB, and Erk1/2 activation, decreased proliferation cell nuclear antigen and receptor for advanced glycation end product expression. Moreover, the plasma fructosamine was significantly reduced in RSV-treated DM rats. Conclusions: RSV alleviated DM-induced vasculopathy through attenuation of advanced glycation end product-receptor for advanced glycation end product-NF-κB signalling pathway.

Original languageEnglish
Pages (from-to)212-222
Number of pages11
JournalDiabetes/Metabolism Research and Reviews
Issue number3
StatePublished - 03 2010


  • Advanced glycation end product
  • Diabetes
  • Receptor for AGE


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