Resveratrol butyrate esters inhibit bpa‐induced liver damage in male offspring rats by modulating antioxidant capacity and gut microbiota

Jin Xian Liao, Yu Wei Chen, Ming Kuei Shih, You Lin Tain, Yao Tsung Yeh, Min Hsi Chiu, Sam K.C. Chang, Chih Yao Hou*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

25 Scopus citations

Abstract

Resveratrol can affect the physiology or biochemistry of offspring in the maternal–fetal animal model. However, it exhibits low bioavailability in humans and animals. Fifteen‐week SD pregnant female rats were orally administered bisphenol A (BPA) and/or resveratrol butyrate ester (RBE), and the male offspring rats (n = 4–8 per group) were evaluated. The results show that RBE treatment (BPA + R30) compared with the BPA group can reduce the damage caused by BPA (p < 0.05). RBE enhanced the expression of selected genes and induced extramedullary hematopoiesis and mononuclear cell infiltration. RBE increased the abundance of S24‐7 and Adlercreutzia in the intestines of the male offspring rats, as well as the concentrations of short‐chain fatty acids (SCFAs) in the feces. RBE also increased the antioxidant capacity of the liver by inducing Nrf2, promoting the expression of HO‐1, SOD, and CAT. It also increased the concentration of intestinal SCFAs, en-hancing the barrier formed by intestinal cells, thereby preventing BPA‐induced metabolic disrup-tion in the male offspring rats, and reduced liver inflammation. This study identified a potential mechanism underlying the protective effects of RBE against the liver damage caused by BPA exposure during the peri‐pregnancy period, and the influence of the gut microbiota on the gut–liver axis in the offspring.

Original languageEnglish
Article number5273
JournalInternational Journal of Molecular Sciences
Volume22
Issue number10
DOIs
StatePublished - 02 05 2021

Bibliographical note

Publisher Copyright:
© 2021 by the author. Licensee MDPI, Basel, Switzerland.

Keywords

  • Bisphenol A (BPA)
  • Gut microbiota
  • Maternal/fetal animal model
  • Offspring
  • Resveratrol butyrate esters (RBE)
  • Short‐chain fatty acids (SCFAs)

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