Retinal toxicity of intravitreal tissue plasminogen activator: Case report and literature review

San Ni Chen; Te Cheng Yang; Cheng Lien Ho; Ya Hui Kuo; Yeung Yip; An Ning Chao

doi:10.1016/S0161-6420(02)01979-6

Retinal toxicity of intravitreal tissue plasminogen activator: Case report and literature review

San Ni Chen^*, Te Cheng Yang, Cheng Lien Ho, Ya Hui Kuo, Yeung Yip, An Ning Chao

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

82 Scopus citations

Abstract

Objective. To present the clinical picture of retinal toxicity of commercial tissue plasminogen activator (tPA). Design: Case report and literature review. Methods: Two successive intravitreal injections of tPA (50 μg) 3 days apart with gas tamponade were given to treat a 49-year-old man with submacular hemorrhage. The adverse consequences of this treatment were monitored. A literature review of retinal toxicity of commercial tPA in animals was also done. Main Outcome Measures: Retinal findings, electroretinograph (ERG) and visual acuity testing. Results: Diffuse pigmentary alterations sparing the posterior pole, poor visual acuity after the absorption of submacular hemorrhage, reduced scotopic and photopic ERG A- and B-waves were noted. Conclusions: This is the first reported case of retinal toxicity of commercial tPA in humans that resembles the descriptions of tPA-mediated retinal toxicity in animal models. The dosage of intravitreal tPA (between 50 and 100 μg) may be toxic to the human retina.

Original language	English
Pages (from-to)	704-708
Number of pages	5
Journal	Ophthalmology
Volume	110
Issue number	4
DOIs	https://doi.org/10.1016/S0161-6420(02)01979-6
State	Published - 01 04 2003
Externally published	Yes

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title = "Retinal toxicity of intravitreal tissue plasminogen activator: Case report and literature review",

abstract = "Objective. To present the clinical picture of retinal toxicity of commercial tissue plasminogen activator (tPA). Design: Case report and literature review. Methods: Two successive intravitreal injections of tPA (50 μg) 3 days apart with gas tamponade were given to treat a 49-year-old man with submacular hemorrhage. The adverse consequences of this treatment were monitored. A literature review of retinal toxicity of commercial tPA in animals was also done. Main Outcome Measures: Retinal findings, electroretinograph (ERG) and visual acuity testing. Results: Diffuse pigmentary alterations sparing the posterior pole, poor visual acuity after the absorption of submacular hemorrhage, reduced scotopic and photopic ERG A- and B-waves were noted. Conclusions: This is the first reported case of retinal toxicity of commercial tPA in humans that resembles the descriptions of tPA-mediated retinal toxicity in animal models. The dosage of intravitreal tPA (between 50 and 100 μg) may be toxic to the human retina.",

author = "Chen, \{San Ni\} and Yang, \{Te Cheng\} and Ho, \{Cheng Lien\} and Kuo, \{Ya Hui\} and Yeung Yip and Chao, \{An Ning\}",

year = "2003",

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doi = "10.1016/S0161-6420(02)01979-6",

language = "英语",

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T1 - Retinal toxicity of intravitreal tissue plasminogen activator

T2 - Case report and literature review

AU - Chen, San Ni

AU - Yang, Te Cheng

AU - Ho, Cheng Lien

AU - Kuo, Ya Hui

AU - Yip, Yeung

AU - Chao, An Ning

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Objective. To present the clinical picture of retinal toxicity of commercial tissue plasminogen activator (tPA). Design: Case report and literature review. Methods: Two successive intravitreal injections of tPA (50 μg) 3 days apart with gas tamponade were given to treat a 49-year-old man with submacular hemorrhage. The adverse consequences of this treatment were monitored. A literature review of retinal toxicity of commercial tPA in animals was also done. Main Outcome Measures: Retinal findings, electroretinograph (ERG) and visual acuity testing. Results: Diffuse pigmentary alterations sparing the posterior pole, poor visual acuity after the absorption of submacular hemorrhage, reduced scotopic and photopic ERG A- and B-waves were noted. Conclusions: This is the first reported case of retinal toxicity of commercial tPA in humans that resembles the descriptions of tPA-mediated retinal toxicity in animal models. The dosage of intravitreal tPA (between 50 and 100 μg) may be toxic to the human retina.

AB - Objective. To present the clinical picture of retinal toxicity of commercial tissue plasminogen activator (tPA). Design: Case report and literature review. Methods: Two successive intravitreal injections of tPA (50 μg) 3 days apart with gas tamponade were given to treat a 49-year-old man with submacular hemorrhage. The adverse consequences of this treatment were monitored. A literature review of retinal toxicity of commercial tPA in animals was also done. Main Outcome Measures: Retinal findings, electroretinograph (ERG) and visual acuity testing. Results: Diffuse pigmentary alterations sparing the posterior pole, poor visual acuity after the absorption of submacular hemorrhage, reduced scotopic and photopic ERG A- and B-waves were noted. Conclusions: This is the first reported case of retinal toxicity of commercial tPA in humans that resembles the descriptions of tPA-mediated retinal toxicity in animal models. The dosage of intravitreal tPA (between 50 and 100 μg) may be toxic to the human retina.

UR - https://www.scopus.com/pages/publications/0242500326

U2 - 10.1016/S0161-6420(02)01979-6

DO - 10.1016/S0161-6420(02)01979-6

M3 - 文章

C2 - 12689889

AN - SCOPUS:0242500326

SN - 0161-6420

VL - 110

SP - 704

EP - 708

JO - Ophthalmology

JF - Ophthalmology

IS - 4

ER -

Retinal toxicity of intravitreal tissue plasminogen activator: Case report and literature review

Abstract

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