Reverse transcriptase inhibitors from Curcuma phaeocaulis

Yu Chi Hou, Yih Shou Hsieh, Chung Chuan Chen, Pei Dawn Lee Chao*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations

Abstract

The rhizome of Curcuma phaeocaulis is widely used in clinical Chinese medicine. Chemical investigation resulted in the isolation of five compounds: palmitic acid (1), curcumenol (2), isocurcumenol (3), zederone (4) and curcumin (5). Among the isolates, curcumenol (2) was the most abundent (yield 0.03 %). The isolated compounds were tested for their effects on the reverse transcriptase activity of Moloney murine leukemia virus. Curcumenol (2), isocurcumenol (3) and curcumin (5) were found effective in inhibiting the reverse transcriptase activity.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalChinese Pharmaceutical Journal
Volume49
Issue number2
StatePublished - 04 1997
Externally publishedYes

Keywords

  • Constituents
  • Curcuma phaeocaulis
  • Reverse transcriptase
  • Zingiberaceae

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