Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea

Hui Chun Huang; Yu Chin Wu; Lee Yung Shih; Woei Chung Lo; Chon Haw Tsai; Woei Cherng Shyu

doi:10.1007/s00415-011-6069-y

Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea

Hui Chun Huang, Yu Chin Wu, Lee Yung Shih, Woei Chung Lo, Chon Haw Tsai^*, Woei Cherng Shyu

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

16 Scopus citations

Abstract

We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[ ¹⁸F]fluoro- 2-deoxy-D-glucose positron emission tomography (FDG PET) and ^99mTc-labeled tropane dopamine transporter ( ^99mTc-TRODAT- 1) single photon emission computed tomography (SPECT). Along with normalization of the hematocrit and clinical symptoms after consecutive phlebotomies, the FDG PET scan and ^99mTc-TRODAT-1 SPECT images returned towards normal. It is hypothesized that the development of polycythemia chorea is associated with a reversible alteration in the corticobasal ganglia metabolism and disturbed dopaminergic function.

Original language	English
Pages (from-to)	2054-2057
Number of pages	4
Journal	Journal of Neurology
Volume	258
Issue number	11
DOIs	https://doi.org/10.1007/s00415-011-6069-y
State	Published - 11 2011
Externally published	Yes

Keywords

Chorea
PET
Polycythemia vera
Tc-TRODAT-1

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10.1007/s00415-011-6069-y

Cite this

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title = "Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea",

abstract = "We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[ 18F]fluoro- 2-deoxy-D-glucose positron emission tomography (FDG PET) and 99mTc-labeled tropane dopamine transporter ( 99mTc-TRODAT- 1) single photon emission computed tomography (SPECT). Along with normalization of the hematocrit and clinical symptoms after consecutive phlebotomies, the FDG PET scan and 99mTc-TRODAT-1 SPECT images returned towards normal. It is hypothesized that the development of polycythemia chorea is associated with a reversible alteration in the corticobasal ganglia metabolism and disturbed dopaminergic function.",

keywords = "Chorea, PET, Polycythemia vera, Tc-TRODAT-1",

author = "Huang, \{Hui Chun\} and Wu, \{Yu Chin\} and Shih, \{Lee Yung\} and Lo, \{Woei Chung\} and Tsai, \{Chon Haw\} and Shyu, \{Woei Cherng\}",

year = "2011",

month = nov,

doi = "10.1007/s00415-011-6069-y",

language = "英语",

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T1 - Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea

AU - Huang, Hui Chun

AU - Wu, Yu Chin

AU - Shih, Lee Yung

AU - Lo, Woei Chung

AU - Tsai, Chon Haw

AU - Shyu, Woei Cherng

PY - 2011/11

Y1 - 2011/11

N2 - We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[ 18F]fluoro- 2-deoxy-D-glucose positron emission tomography (FDG PET) and 99mTc-labeled tropane dopamine transporter ( 99mTc-TRODAT- 1) single photon emission computed tomography (SPECT). Along with normalization of the hematocrit and clinical symptoms after consecutive phlebotomies, the FDG PET scan and 99mTc-TRODAT-1 SPECT images returned towards normal. It is hypothesized that the development of polycythemia chorea is associated with a reversible alteration in the corticobasal ganglia metabolism and disturbed dopaminergic function.

AB - We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[ 18F]fluoro- 2-deoxy-D-glucose positron emission tomography (FDG PET) and 99mTc-labeled tropane dopamine transporter ( 99mTc-TRODAT- 1) single photon emission computed tomography (SPECT). Along with normalization of the hematocrit and clinical symptoms after consecutive phlebotomies, the FDG PET scan and 99mTc-TRODAT-1 SPECT images returned towards normal. It is hypothesized that the development of polycythemia chorea is associated with a reversible alteration in the corticobasal ganglia metabolism and disturbed dopaminergic function.

KW - Chorea

KW - PET

KW - Polycythemia vera

KW - Tc-TRODAT-1

UR - https://www.scopus.com/pages/publications/84857682214

U2 - 10.1007/s00415-011-6069-y

DO - 10.1007/s00415-011-6069-y

M3 - 文章

C2 - 21559940

AN - SCOPUS:84857682214

SN - 0340-5354

VL - 258

SP - 2054

EP - 2057

JO - Journal of Neurology

JF - Journal of Neurology

IS - 11

ER -

Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea

Abstract

Keywords

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