Review on impedance detection of cellular responses in micro/nano environment

Kin Fong Lei*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

In general, cell culture-based assays, investigations of cell number, viability, and metabolic activities during culture periods, are commonly performed to study the cellular responses under various culture conditions explored. Quantification of cell numbers can provide the information of cell proliferation. Cell viability study can understand the percentage of cell death under a specific tested substance. Monitoring of the metabolic activities is an important index for the study of cell physiology. Based on the development of microfluidic technology, microfluidic systems incorporated with impedance measurement technique, have been reported as a new analytical approach for cell culture-based assays. The aim of this article is to review recent developments on the impedance detection of cellular responses in micro/nano environment. These techniques provide an effective and efficient technique for cell culture-based assays.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalMicromachines
Volume5
Issue number1
DOIs
StatePublished - 2014

Keywords

  • Cell culture
  • Cellular responses
  • Impedance measurement
  • Microfluidics

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