TY - JOUR
T1 - RhesusBase PopGateway
T2 - Genome-Wide Population Genetics Atlas in Rhesus Macaque
AU - Zhong, Xiaoming
AU - Peng, Jiguang
AU - Shen, Qing Sunny
AU - Chen, Jia Yu
AU - Gao, Han
AU - Luan, Xuke
AU - Yan, Shouyu
AU - Huang, Xin
AU - Zhang, Shi Jian
AU - Xu, Luying
AU - Zhang, Xiuqin
AU - Tan, Bertrand Chin Ming
AU - Li, Chuan Yun
N1 - Publisher Copyright:
© 2016 The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Although population genetics studies have significantly accelerated the evolutionary and functional interrogations of genes and regulations, limited polymorphism data are available for rhesus macaque, the model animal closely related to human. Here, we report the first genome-wide effort to identify and visualize the population genetics profile in rhesus macaque. On the basis of the whole-genome sequencing of 31 independent macaque animals, we profiled a comprehensive polymorphism map with 46,146,548 sites. The allele frequency for each polymorphism site, the haplotype structure, as well as multiple population genetics parameters were then calculated on a genome-wide scale. We further developed a specific interface, the RhesusBase PopGateway, to facilitate the visualization of these annotations, and highlighted the applications of this highly integrative platform in clarifying the selection signatures of genes and regulations in the context of the primate evolution. Overall, the updated RhesusBase provides a comprehensive monkey population genetics framework for in-depth evolutionary studies of human biology.
AB - Although population genetics studies have significantly accelerated the evolutionary and functional interrogations of genes and regulations, limited polymorphism data are available for rhesus macaque, the model animal closely related to human. Here, we report the first genome-wide effort to identify and visualize the population genetics profile in rhesus macaque. On the basis of the whole-genome sequencing of 31 independent macaque animals, we profiled a comprehensive polymorphism map with 46,146,548 sites. The allele frequency for each polymorphism site, the haplotype structure, as well as multiple population genetics parameters were then calculated on a genome-wide scale. We further developed a specific interface, the RhesusBase PopGateway, to facilitate the visualization of these annotations, and highlighted the applications of this highly integrative platform in clarifying the selection signatures of genes and regulations in the context of the primate evolution. Overall, the updated RhesusBase provides a comprehensive monkey population genetics framework for in-depth evolutionary studies of human biology.
KW - RhesusBase
KW - population genetics
KW - primate evolution
KW - rhesus macaque
KW - whole-genome sequencing
UR - http://www.scopus.com/inward/record.url?scp=84969939751&partnerID=8YFLogxK
U2 - 10.1093/molbev/msw025
DO - 10.1093/molbev/msw025
M3 - 文章
C2 - 26882984
AN - SCOPUS:84969939751
SN - 0737-4038
VL - 33
SP - 1370
EP - 1375
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
IS - 5
ER -