Abstract
A 42-year-old male presented with generalized massive lymphadenopathy, fever, weight loss and numerous cutaneous nodules. Peripheral blood examination showed lymphocytosis with small lymphocytes, and immunophenotyping revealed B-cell chronic lymphocytic leukemia (CLL). Cytogenetic analysis of bone marrow aspirate revealed a clonal abnormality of chromosome 11. Lymph node biopsies showed a B-immunoblastic lymphoma. A diagnosis of Richter's syndrome (RS) was made. The patient did not respond to doxorubicin, cyclophosphamide, vincristine and prednisolone (CHOP) and died of progressive disease with pneumonia and respiratory failure 9 months later. CLL is not common among Chinese people and RS is extremely rare.
| Original language | English |
|---|---|
| Pages (from-to) | 686-688 |
| Number of pages | 3 |
| Journal | Journal of the Formosan Medical Association |
| Volume | 94 |
| Issue number | 11 |
| State | Published - 11 1995 |
| Externally published | Yes |