TY - JOUR
T1 - Risk Factors for Development of Septic Shock in Patients with Urinary Tract Infection
AU - Hsiao, Chih Yen
AU - Yang, Huang Yu
AU - Chang, Chih Hsiang
AU - Lin, Hsing Lin
AU - Wu, Chao Yi
AU - Hsiao, Meng Chang
AU - Hung, Peir Haur
AU - Liu, Su Hsun
AU - Weng, Cheng Hao
AU - Lee, Cheng Chia
AU - Yen, Tzung Hai
AU - Chen, Yung Chang
AU - Wu, Tzu Chin
N1 - Publisher Copyright:
© 2015 Chih-Yen Hsiao et al.
PY - 2015
Y1 - 2015
N2 - Introduction. Severe sepsis and septic shock are associated with substantial mortality. However, few studies have assessed the risk of septic shock among patients who suffered from urinary tract infection (UTI). Materials and Methods. This retrospective study recruited UTI cases from an acute care hospital between January 2006 and October 2012 with prospective data collection. Results. Of the 710 participants admitted for UTI, 80 patients (11.3%) had septic shock. The rate of bacteremia is 27.9%; acute kidney injury is 12.7%, and the mortality rate is 0.28%. Multivariable logistic regression analyses indicated that coronary artery disease (CAD) (OR: 2.521, 95% CI: 1.129-5.628, P=0.024), congestive heart failure (CHF) (OR: 4.638, 95% CI: 1.908-11.273, P=0.001), and acute kidney injury (AKI) (OR: 2.992, 95% CI: 1.610-5.561, P=0.001) were independently associated with septic shock in patients admitted with UTI. In addition, congestive heart failure (female, OR: 4.076, 95% CI: 1.355-12.262, P=0.012; male, OR: 5.676, 95% CI: 1.103-29.220, P=0.038, resp.) and AKI (female, OR: 2.995, 95% CI: 1.355-6.621, P=0.007; male, OR: 3.359, 95% CI: 1.158-9.747, P=0.026, resp.) were significantly associated with risk of septic shock in both gender groups. Conclusion. This study showed that patients with a medical history of CAD or CHF have a higher risk of shock when admitted for UTI treatment. AKI, a complication of UTI, was also associated with septic shock. Therefore, prompt and aggressive management is recommended for those with higher risks to prevent subsequent treatment failure in UTI patients.
AB - Introduction. Severe sepsis and septic shock are associated with substantial mortality. However, few studies have assessed the risk of septic shock among patients who suffered from urinary tract infection (UTI). Materials and Methods. This retrospective study recruited UTI cases from an acute care hospital between January 2006 and October 2012 with prospective data collection. Results. Of the 710 participants admitted for UTI, 80 patients (11.3%) had septic shock. The rate of bacteremia is 27.9%; acute kidney injury is 12.7%, and the mortality rate is 0.28%. Multivariable logistic regression analyses indicated that coronary artery disease (CAD) (OR: 2.521, 95% CI: 1.129-5.628, P=0.024), congestive heart failure (CHF) (OR: 4.638, 95% CI: 1.908-11.273, P=0.001), and acute kidney injury (AKI) (OR: 2.992, 95% CI: 1.610-5.561, P=0.001) were independently associated with septic shock in patients admitted with UTI. In addition, congestive heart failure (female, OR: 4.076, 95% CI: 1.355-12.262, P=0.012; male, OR: 5.676, 95% CI: 1.103-29.220, P=0.038, resp.) and AKI (female, OR: 2.995, 95% CI: 1.355-6.621, P=0.007; male, OR: 3.359, 95% CI: 1.158-9.747, P=0.026, resp.) were significantly associated with risk of septic shock in both gender groups. Conclusion. This study showed that patients with a medical history of CAD or CHF have a higher risk of shock when admitted for UTI treatment. AKI, a complication of UTI, was also associated with septic shock. Therefore, prompt and aggressive management is recommended for those with higher risks to prevent subsequent treatment failure in UTI patients.
UR - http://www.scopus.com/inward/record.url?scp=84941075394&partnerID=8YFLogxK
U2 - 10.1155/2015/717094
DO - 10.1155/2015/717094
M3 - 文章
C2 - 26380292
AN - SCOPUS:84941075394
SN - 2314-6133
VL - 2015
JO - BioMed Research International
JF - BioMed Research International
M1 - 717094
ER -