Risk factors for seizures after first-time ischemic stroke by Magnetic Resonance Imaging

I. Hui Chiang, Wen Neng Chang, Wei Che Lin, Ku Chou Chang, Nai Wen Tsai, Chia Wei Liou, Tzu Kuan Sun, Song Seng Loke, Chao Tung Chen, Chih Fang Huang, Wei Cheng Huang, Pei Ming Wang, Cheng Hsien Lu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations

Abstract

Background: Seizures are important neurological complications of ischemic stroke. There is a need to further clrify the risk factors of seizures following ischemic stroke and predict those who will require treatment. Methods: One hundred and forty-three (143) first-time ischemic stroke patients were enrolled in this one-year (2002) retrospective study. Prognostic variables were analyzed based on the Cox's proportional hazards model after a minimum follow-up period of six years. Results: Seizures occurred in 13 first-time ischemic stroke patients, including acute symptomatic seizures in two (1.4%) and unprovoked seizures in 11 (7.7%). Only one progressed to status epilepticus during hospitalization. After six years of follow-up, the median (inter-quartile range) Glasgow Outcome Scale (GOS) was 3 (3,4) for patients with seizures and 4 (3,4) for those without seizures. Regarding seizure control after discharge in the 13 cases, 12 were seizure-free with or without anti-epileptic drugs and one had 1-3 seizures per year. Only the presence of cortical distribution of ischemic infarction (p=0.009, OR=5.549, 95% 0=1.53-20.19) was independently associated with seizures by the Cox's proportional hazards model. Discussion: The incidence of seizures following first-time ischemic stroke is low and may have delayed manifestation. Cortical distribution of the ischemic infarction is a risk factors for seizures.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalActa Neurologica Taiwanica
Volume19
Issue number1
StatePublished - 03 2010

Keywords

  • First-ever ischemic stroke
  • Risk factors
  • Seizure

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