Risk factors of coexisting septic spondylitis and arthritis: A case‐control study in a tertiary referral hospital

Sheng Fen Wang, Po Liang Lai, Hsiang Fu Liu, Tsung Ting Tsai, Yu Chih Lin, Yun Da Li, Ping Yeh Chiu, Ming Kai Hsieh, Fu Cheng Kao*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


Introduction: In patients under immunosuppression or severe sepsis, it is sometimes man-ifested as coexisting septic arthritis and spondylitis. The aim of this study is to evaluate and inves-tigate the risk factors of infectious spondylitis associated with septic arthritis. Methods: The study retrospectively reviewed the patients diagnosed with infectious spondylitis between January 2010 and September 2018 for risk factors of coexisting major joint septic arthritis. Results: A total of 10 patients with infectious spondylitis and coexisting septic arthritis comprised the study group. Fifty matched patients with solely infectious spondylitis were selected as the control group. Major risk factors include preoperative C‐reactive protein (p = 0.001), hypoalbuminemia (p = 0.011), history of total joint replacement (p < 0.001), duration of preoperative antibiotics treatment (p = 0.038) and psoas muscle abscess (p < 0.001). Conclusion: Infectious spondylitis and septic arthritis are thought of as medical emergencies due to their high mortality and morbidity. Our study evaluated 5 risk factors as significant major findings: hypoalbuminemia (<3.4 g/dL), higher preoperative CRP (>130 mg/L), psoas muscle abscess, longer preoperative antibiotics treatment (>8 days) and history of total joint replacement. Clinicians should pay attention to the patients with those five factors to detect the coexisting infections as early as possible.

Original languageEnglish
Article number5345
JournalJournal of Clinical Medicine
Issue number22
StatePublished - 01 11 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Li-censee MDPI, Basel, Switzerland.


  • Hypoalbuminemia
  • Infectious spondylitis
  • Psoas abscess
  • Septic arthritis


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