Risk factors of multidrug-resistant Acinetobacter baumannii recurrence after successful eradication in ventilated patients

Chiung Yu Lin, Yu Mu Chen, Meng Chih Lin, Yu Ping Chang, Tung Ying Chao, Chin Chou Wang, Yuh Chyn Tsai, Lien Shi Shen, Chin Ling Li, An Shen Lin*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

14 Scopus citations

Abstract

Background Clinically, multidrug-resistant Acinetobacter baumannii (MDR-AB) recurrence is found in some patients although identified as successfully eradicated. We aim to discover the characteristics of patients with MDR-AB recurrence in the respiratory tract. Methods We retrospectively collected 106 chronic respiratory failure patients with MDR-AB harvest in pulmonary secretion culture. Results MDR-AB was successfully eradicated in 69 patients. Diabetes mellitus (p = 0.030, odds ratio [OR]: 2.7, 95% confidence interval [CI]: 1.1–6.4) and acute respiratory distress syndrome (p = 0.001, OR = 4.8, 95% CI: 1.8–12.7) reduce the MDR-AB eradication rate. Besides, a classification of colonization or infection was made beyond the 69 MDR-AB eradicated patients. In the colonization group, diabetes mellitus (p = 0.009; OR = 5.1, 95% CI: 1.5–17.6) is the only independent factor to increase the recurrence rate. Glycated hemoglobin level is also analyzed for each group to investigate diabetes control effect, but no significant difference found. Conclusions Diabetes mellitus is a risk factor of MDR-AB recurrence among MDR-AB-colonized patients; the impact of localized pneumonia patch in MDR-AB-infected patients requires further study to be clarified.

Original languageEnglish
Pages (from-to)130-138
Number of pages9
JournalBiomedical Journal
Volume39
Issue number2
DOIs
StatePublished - 01 04 2016

Bibliographical note

Publisher Copyright:
© 2016 Chang Gung University

Keywords

  • Chronic respiratory failure
  • Multidrug-resistant Acinetobacter baumannii
  • Recurrence
  • Risk factor

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