TY - JOUR
T1 - RNA recombination in hepatitis delta virus
T2 - Implications regarding the abilities of mammalian RNA polymerases
AU - Chao, Mei
PY - 2007/8
Y1 - 2007/8
N2 - Hepatitis delta virus (HDV) requires the surface antigens of hepatitis B virus (HBV) for packaging and transmission, but replicates its RNA in an HBV-independent fashion. HDV contains a 1.7-kb circular RNA genome that is folded into an unbranched rod-like structure via intramolecular base-pairing, and possesses ribozyme activity. The HDV genome does not encode an RNA-dependent RNA polymerase (RdRp), but is instead replicated by host RNA polymerase(s) via a rolling-circle mechanism. As such, HDV is similar to the viroid plant pathogens. Recent findings suggest that HDV can also undergo template-switching recombination, a well-documented process that has been found in a large number of RdRp-encoding RNA viruses and is thought to affect viral evolution and pathogenesis. This mini-review examines HDV RNA recombination and how it may improve our understanding of the capacities of host RNA polymerases beyond typical DNA-directed transcription, and speculates on the role of host RNA polymerase-directed RNA template-switching in the origin of HDV.
AB - Hepatitis delta virus (HDV) requires the surface antigens of hepatitis B virus (HBV) for packaging and transmission, but replicates its RNA in an HBV-independent fashion. HDV contains a 1.7-kb circular RNA genome that is folded into an unbranched rod-like structure via intramolecular base-pairing, and possesses ribozyme activity. The HDV genome does not encode an RNA-dependent RNA polymerase (RdRp), but is instead replicated by host RNA polymerase(s) via a rolling-circle mechanism. As such, HDV is similar to the viroid plant pathogens. Recent findings suggest that HDV can also undergo template-switching recombination, a well-documented process that has been found in a large number of RdRp-encoding RNA viruses and is thought to affect viral evolution and pathogenesis. This mini-review examines HDV RNA recombination and how it may improve our understanding of the capacities of host RNA polymerases beyond typical DNA-directed transcription, and speculates on the role of host RNA polymerase-directed RNA template-switching in the origin of HDV.
KW - Hepatitis delta virus
KW - RNA polymerases
KW - RNA recombination
KW - RNA-dependent RNA replication
KW - Template-switching
KW - Virus evolution
UR - https://www.scopus.com/pages/publications/34447297294
U2 - 10.1016/j.virusres.2007.01.003
DO - 10.1016/j.virusres.2007.01.003
M3 - 文献综述
C2 - 17296240
AN - SCOPUS:34447297294
SN - 0168-1702
VL - 127
SP - 208
EP - 215
JO - Virus Research
JF - Virus Research
IS - 2
ER -
