Roles of nitric oxide and asymmetric dimethylarginine in pregnancy and fetal programming

Li Tung Huang; Chih Sung Hsieh; Kow Aung Chang; You Lin Tain

doi:10.3390/ijms131114606

Roles of nitric oxide and asymmetric dimethylarginine in pregnancy and fetal programming

Li Tung Huang, Chih Sung Hsieh, Kow Aung Chang, You Lin Tain^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

Abstract

Nitric oxide (NO) regulates placental blood flow and actively participates in trophoblast invasion and placental development. Asymmetric dimethylarginine (ADMA) can inhibit NO synthase, which generates NO. ADMA has been associated with uterine artery flow disturbances such as preeclampsia. Substantial experimental evidence has reliably supported the hypothesis that an adverse in utero environment plays a role in postnatal physiological and pathophysiological programming. Growing evidence suggests that the placental nitrergic system is involved in epigenetic fetal programming. In this review, we discuss the roles of NO and ADMA in normal and compromised pregnancies as well as the link between placental insufficiency and epigenetic fetal programming.

Original language	English
Pages (from-to)	14606-14622
Number of pages	17
Journal	International Journal of Molecular Sciences
Volume	13
Issue number	11
DOIs	https://doi.org/10.3390/ijms131114606
State	Published - 2012
Externally published	Yes

Keywords

Asymmetric dimethylarginine
Fetal programming
Nitrergic
Nitric oxide
Placenta

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10.3390/ijms131114606

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abstract = "Nitric oxide (NO) regulates placental blood flow and actively participates in trophoblast invasion and placental development. Asymmetric dimethylarginine (ADMA) can inhibit NO synthase, which generates NO. ADMA has been associated with uterine artery flow disturbances such as preeclampsia. Substantial experimental evidence has reliably supported the hypothesis that an adverse in utero environment plays a role in postnatal physiological and pathophysiological programming. Growing evidence suggests that the placental nitrergic system is involved in epigenetic fetal programming. In this review, we discuss the roles of NO and ADMA in normal and compromised pregnancies as well as the link between placental insufficiency and epigenetic fetal programming.",

keywords = "Asymmetric dimethylarginine, Fetal programming, Nitrergic, Nitric oxide, Placenta",

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AU - Hsieh, Chih Sung

AU - Chang, Kow Aung

AU - Tain, You Lin

PY - 2012

Y1 - 2012

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AB - Nitric oxide (NO) regulates placental blood flow and actively participates in trophoblast invasion and placental development. Asymmetric dimethylarginine (ADMA) can inhibit NO synthase, which generates NO. ADMA has been associated with uterine artery flow disturbances such as preeclampsia. Substantial experimental evidence has reliably supported the hypothesis that an adverse in utero environment plays a role in postnatal physiological and pathophysiological programming. Growing evidence suggests that the placental nitrergic system is involved in epigenetic fetal programming. In this review, we discuss the roles of NO and ADMA in normal and compromised pregnancies as well as the link between placental insufficiency and epigenetic fetal programming.

KW - Asymmetric dimethylarginine

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Roles of nitric oxide and asymmetric dimethylarginine in pregnancy and fetal programming

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