Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphella antipathies

Hsu Ming Chung; Wei Hsien Wang; Tsong Long Hwang; Jan Jung Li; Lee Shing Fang; Yang Chang Wu; Ping Jyun Sung

doi:10.3390/molecules190812320

Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphella antipathies

Hsu Ming Chung, Wei Hsien Wang, Tsong Long Hwang, Jan Jung Li, Lee Shing Fang, Yang Chang Wu^*, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

Two new 4,5-seco-caryophyllane sesquiterpenoids, rumphellaones B (1) and C (2), which were found to possess unprecedented γ-lactone moieties, were obtained from the gorgonian coral Rumphella antipathies. The structures of 1 and 2 were elucidated by spectroscopic methods and compound 2 was found to display modest inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils at a concentration of 10 μg/mL.

Original language	English
Pages (from-to)	12320-12327
Number of pages	8
Journal	Molecules
Volume	19
Issue number	8
DOIs	https://doi.org/10.3390/molecules190812320
State	Published - 08 2014

Keywords

Anti-inflammatory activity
Caryophyllane-type sesquiterpenoid
Rumphella antipathies
Rumphellaones B and C.

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10.3390/molecules190812320

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title = "Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphella antipathies",

abstract = "Two new 4,5-seco-caryophyllane sesquiterpenoids, rumphellaones B (1) and C (2), which were found to possess unprecedented γ-lactone moieties, were obtained from the gorgonian coral Rumphella antipathies. The structures of 1 and 2 were elucidated by spectroscopic methods and compound 2 was found to display modest inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils at a concentration of 10 μg/mL.",

keywords = "Anti-inflammatory activity, Caryophyllane-type sesquiterpenoid, Rumphella antipathies, Rumphellaones B and C.",

author = "Chung, {Hsu Ming} and Wang, {Wei Hsien} and Hwang, {Tsong Long} and Li, {Jan Jung} and Fang, {Lee Shing} and Wu, {Yang Chang} and Sung, {Ping Jyun}",

year = "2014",

month = aug,

doi = "10.3390/molecules190812320",

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volume = "19",

pages = "12320--12327",

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T1 - Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphella antipathies

AU - Chung, Hsu Ming

AU - Wang, Wei Hsien

AU - Hwang, Tsong Long

AU - Li, Jan Jung

AU - Fang, Lee Shing

AU - Wu, Yang Chang

AU - Sung, Ping Jyun

PY - 2014/8

Y1 - 2014/8

N2 - Two new 4,5-seco-caryophyllane sesquiterpenoids, rumphellaones B (1) and C (2), which were found to possess unprecedented γ-lactone moieties, were obtained from the gorgonian coral Rumphella antipathies. The structures of 1 and 2 were elucidated by spectroscopic methods and compound 2 was found to display modest inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils at a concentration of 10 μg/mL.

AB - Two new 4,5-seco-caryophyllane sesquiterpenoids, rumphellaones B (1) and C (2), which were found to possess unprecedented γ-lactone moieties, were obtained from the gorgonian coral Rumphella antipathies. The structures of 1 and 2 were elucidated by spectroscopic methods and compound 2 was found to display modest inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils at a concentration of 10 μg/mL.

KW - Anti-inflammatory activity

KW - Caryophyllane-type sesquiterpenoid

KW - Rumphella antipathies

KW - Rumphellaones B and C.

UR - http://www.scopus.com/inward/record.url?scp=84906662014&partnerID=8YFLogxK

U2 - 10.3390/molecules190812320

DO - 10.3390/molecules190812320

M3 - 文章

C2 - 25153859

AN - SCOPUS:84906662014

SN - 1420-3049

VL - 19

SP - 12320

EP - 12327

JO - Molecules

JF - Molecules

IS - 8

ER -

Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphella antipathies

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Keywords

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