S-values calculated from a tomographic head/brain model for brain imaging

Tsi Chian Chao*, X. George Xu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

26 Scopus citations


A tomographic head/brain model was developed from the Visible Human images and used to calculate S-values for brain imaging procedures. This model contains 15 segmented sub-regions including caudate nucleus, cerebellum, cerebral cortex, cerebral white matter, corpus callosum, eyes, lateral ventricles, lenses, lentiform nucleus, optic chiasma, optic nerve, pons and middle cerebellar peduncle, skull CSF, thalamus and thyroid. S-values for C-11, O-15, F-18, Tc-99m and I-123 have been calculated using this model and a Monte Carlo code, EGS4. Comparison of the calculated S-values with those calculated from the MIRD (1999) stylized head/brain model shows significant differences. In many cases, the stylized head/brain model resulted in smaller S-values (as much as 88%), suggesting that the doses to a specific patient similar to the Visible Man could have been underestimated using the existing clinical dosimetry.

Original languageEnglish
Pages (from-to)4971-4984
Number of pages14
JournalPhysics in Medicine and Biology
Issue number21
StatePublished - 07 11 2004


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