Safety and effectiveness of remdesivir for the treatment of COVID-19 patients with end-stage renal disease: A retrospective cohort study

Yan Bo Huang, Chip Jin Ng, Cherng-Hsun Chiu, Chung Hsien Chaou, Shi Ying Gao, Shou Yen Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

Background: Remdesivir has been used to treat severe coronavirus 2019 (COVID-19); however, its safety and effectiveness in patients remain unclear. This study aimed to investigate the safety and effectiveness of remdesivir in patients with COVID-19 with end-stage renal disease (ESRD). Methods: This retrospective study used the Chang Gung Research Database (CGRD) and extracted data from 21,621 adult patients with COVID-19 diagnosed between April 2021 and September 2022. The patients were divided into groups based on their remdesivir use and the presence of ESRD. The adverse effects of remdesivir and their outcomes were analyzed after propensity score matching. Results: To compare the adverse effects of remdesivir, propensity scores were used for one-to-one matching between patients with and without ESRD treated with remdesivir (N = 110). There were no statistically significant differences in heart rates, blood glucose levels, variations in hemoglobin levels before and after remdesivir use, or liver function between the two groups after remdesivir use. A comparison was made between patients with ESRD using remdesivir and those not using remdesivir after propensity score matching (N = 44). Although a shorter length of stay (LOS), lower intensive care unit (ICU) admission rate, and lower intubation rate were noted in the ESRD group treated with remdesivir, the difference was not statistically significant. Conclusion: Remdesivir is safe for use in patients with COVID-19 and ESRD; no increased adverse effects were noted compared with patients without ESRD. However, the effectiveness of remdesivir use in patients with COVID-19 and ESRD remains uncertain.

Original languageEnglish
Pages (from-to)76-84
Number of pages9
JournalJournal of Microbiology, Immunology and Infection
Volume57
Issue number1
DOIs
StatePublished - 02 2024

Bibliographical note

Copyright © 2023. Published by Elsevier B.V.

Keywords

  • COVID-19
  • End-stage renal disease
  • Remdesivir
  • Side effects
  • Adenosine Monophosphate/analogs & derivatives
  • COVID-19 Drug Treatment
  • Kidney Failure, Chronic/complications
  • Alanine/analogs & derivatives
  • Humans
  • Adult
  • Retrospective Studies

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