Salvia miltiorrhiza protects endothelial dysfunction against mitochondrial oxidative stress

Yu Chen Cheng; I. Ling Hung; Yen Nung Liao; Wen Long Hu; Yu Chiang Hung

doi:10.3390/life11111257

Salvia miltiorrhiza protects endothelial dysfunction against mitochondrial oxidative stress

Yu Chen Cheng, I. Ling Hung, Yen Nung Liao, Wen Long Hu, Yu Chiang Hung^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Salvia miltiorrhiza (SM) is a common traditional Chinese medicine used in the treatment of cardiovascular and cerebrovascular diseases. Endothelial dysfunction plays an important role in the pathology of cardiovascular diseases. Endothelial dysfunction may induce inflammation and change vascular tone and permeability. The main pathological mechanism of endothelial dysfunction is the formation of reactive oxygen species (ROS). Mitochondria are the main source of energy and can also produce large amounts of ROS. Recent studies have shown that extracts of SM have antioxidative, anti-inflammatory, and antithrombus properties. In this review, we discuss the mechanism of oxidative stress in the mitochondria, endothelial dysfunction, and the role of SM in these oxidative events.

Original language	English
Article number	1257
Journal	Life
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/life11111257
State	Published - 11 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cardiovascular disease
Endothelial dysfunction
Herbal medicine
Mitochondria
Oxidative stress
Reactive oxygen species
Salvia miltiorrhiza
TCM

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/life11111257

Cite this

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title = "Salvia miltiorrhiza protects endothelial dysfunction against mitochondrial oxidative stress",

abstract = "Salvia miltiorrhiza (SM) is a common traditional Chinese medicine used in the treatment of cardiovascular and cerebrovascular diseases. Endothelial dysfunction plays an important role in the pathology of cardiovascular diseases. Endothelial dysfunction may induce inflammation and change vascular tone and permeability. The main pathological mechanism of endothelial dysfunction is the formation of reactive oxygen species (ROS). Mitochondria are the main source of energy and can also produce large amounts of ROS. Recent studies have shown that extracts of SM have antioxidative, anti-inflammatory, and antithrombus properties. In this review, we discuss the mechanism of oxidative stress in the mitochondria, endothelial dysfunction, and the role of SM in these oxidative events.",

keywords = "Cardiovascular disease, Endothelial dysfunction, Herbal medicine, Mitochondria, Oxidative stress, Reactive oxygen species, Salvia miltiorrhiza, TCM",

author = "Cheng, {Yu Chen} and Hung, {I. Ling} and Liao, {Yen Nung} and Hu, {Wen Long} and Hung, {Yu Chiang}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

doi = "10.3390/life11111257",

language = "英语",

volume = "11",

journal = "Life",

issn = "2075-1729",

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T1 - Salvia miltiorrhiza protects endothelial dysfunction against mitochondrial oxidative stress

AU - Cheng, Yu Chen

AU - Hung, I. Ling

AU - Liao, Yen Nung

AU - Hu, Wen Long

AU - Hung, Yu Chiang

PY - 2021/11

Y1 - 2021/11

N2 - Salvia miltiorrhiza (SM) is a common traditional Chinese medicine used in the treatment of cardiovascular and cerebrovascular diseases. Endothelial dysfunction plays an important role in the pathology of cardiovascular diseases. Endothelial dysfunction may induce inflammation and change vascular tone and permeability. The main pathological mechanism of endothelial dysfunction is the formation of reactive oxygen species (ROS). Mitochondria are the main source of energy and can also produce large amounts of ROS. Recent studies have shown that extracts of SM have antioxidative, anti-inflammatory, and antithrombus properties. In this review, we discuss the mechanism of oxidative stress in the mitochondria, endothelial dysfunction, and the role of SM in these oxidative events.

AB - Salvia miltiorrhiza (SM) is a common traditional Chinese medicine used in the treatment of cardiovascular and cerebrovascular diseases. Endothelial dysfunction plays an important role in the pathology of cardiovascular diseases. Endothelial dysfunction may induce inflammation and change vascular tone and permeability. The main pathological mechanism of endothelial dysfunction is the formation of reactive oxygen species (ROS). Mitochondria are the main source of energy and can also produce large amounts of ROS. Recent studies have shown that extracts of SM have antioxidative, anti-inflammatory, and antithrombus properties. In this review, we discuss the mechanism of oxidative stress in the mitochondria, endothelial dysfunction, and the role of SM in these oxidative events.

KW - Cardiovascular disease

KW - Endothelial dysfunction

KW - Herbal medicine

KW - Mitochondria

KW - Oxidative stress

KW - Reactive oxygen species

KW - Salvia miltiorrhiza

KW - TCM

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U2 - 10.3390/life11111257

DO - 10.3390/life11111257

M3 - 文献综述

AN - SCOPUS:85119674290

SN - 2075-1729

VL - 11

JO - Life

JF - Life

IS - 11

M1 - 1257

ER -

Salvia miltiorrhiza protects endothelial dysfunction against mitochondrial oxidative stress

Abstract

Bibliographical note

Keywords

UN SDGs

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