Abstract
Scavenger receptors (SRs) are a structurally diverse family of innately encoded pattern recognition receptors that are mainly expressed on professional phagocytes and typically bind multiple ligands comprising nonself and modified self. Receptor-ligand interaction can trigger endocytosis, phagocytosis, adhesion, and signaling, and frequently depends on collaboration with non-SR receptors. The present article summarizes structure-function characteristics of SRs throughout evolution, focuses more specifically on innate immune mechanisms and finally links physiological functions of SRs to disease phenotypes and therapeutic advances.
| Original language | English |
|---|---|
| Title of host publication | Functional Cell Biology |
| Publisher | Elsevier Inc. |
| Pages | 727-740 |
| Number of pages | 14 |
| Volume | 3 |
| ISBN (Electronic) | 9780123944474 |
| ISBN (Print) | 9780123947963 |
| DOIs | |
| State | Published - 2016 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Inc. All rights reserved.
Keywords
- (Apo)lipoprotein
- Adhesion
- Atherosclerosis
- Cholesterol transport
- Endocytosis
- Extracellular matrix
- Inflammation
- Lipid transport
- Macrophage
- Pathogen-associated molecular pattern (PAMP)
- Pattern recognition receptor (PRR)
- Phagocytosis
- Scavenger receptor
- Signaling
- Tumor-associated macrophage