Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them

Bi Jiuan Liou; Hsun Shuo Chang; Guei Jane Wang; Michael Y. Chiang; Chang Hui Liao; Chu Hung Lin; Ih Sheng Chen

doi:10.1016/j.phytochem.2011.01.006

Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them

Bi Jiuan Liou, Hsun Shuo Chang, Guei Jane Wang, Michael Y. Chiang, Chang Hui Liao, Chu Hung Lin, Ih Sheng Chen^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

18 Scopus citations

Abstract

Seven sesquiterpenoids, hiiranlactones A-D (1-4), (-)-ent-6α- methoxyeudesm-4(15)-en-1β-ol (5), (+)-villosine (6), hiiranepoxide (7), and one triterpenoid, hiiranterpenone (8), together with 22 known compounds, were isolated from the leaves of Neolitsea hiiranensis (Lauraceae). Their structures were elucidated by spectroscopic analysis and single crystal X-ray diffraction. Among the isolates, hiiranlactone B (2) and hiiranlactone D (4) exhibited inhibitory activity against fMLP-induced superoxide production by human neutrophils with IC₅₀ values of 21.86 ± 3.97 and 25.78 ± 4.77 μM, respectively.

Original language	English
Pages (from-to)	415-422
Number of pages	8
Journal	Phytochemistry
Volume	72
Issue number	4-5
DOIs	https://doi.org/10.1016/j.phytochem.2011.01.006
State	Published - 04 2011

Keywords

Anti-inflammatory activity
Lauraceae
Leaves
Neolitsea hiiranensis
Sesquiterpenoid
Triterpenoid

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10.1016/j.phytochem.2011.01.006

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@article{4fcf16e1eb624b1b97873e8094c49b87,

title = "Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them",

abstract = "Seven sesquiterpenoids, hiiranlactones A-D (1-4), (-)-ent-6α- methoxyeudesm-4(15)-en-1β-ol (5), (+)-villosine (6), hiiranepoxide (7), and one triterpenoid, hiiranterpenone (8), together with 22 known compounds, were isolated from the leaves of Neolitsea hiiranensis (Lauraceae). Their structures were elucidated by spectroscopic analysis and single crystal X-ray diffraction. Among the isolates, hiiranlactone B (2) and hiiranlactone D (4) exhibited inhibitory activity against fMLP-induced superoxide production by human neutrophils with IC50 values of 21.86 ± 3.97 and 25.78 ± 4.77 μM, respectively.",

keywords = "Anti-inflammatory activity, Lauraceae, Leaves, Neolitsea hiiranensis, Sesquiterpenoid, Triterpenoid",

author = "Liou, {Bi Jiuan} and Chang, {Hsun Shuo} and Wang, {Guei Jane} and Chiang, {Michael Y.} and Liao, {Chang Hui} and Lin, {Chu Hung} and Chen, {Ih Sheng}",

year = "2011",

month = apr,

doi = "10.1016/j.phytochem.2011.01.006",

language = "英语",

volume = "72",

pages = "415--422",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd",

number = "4-5",

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TY - JOUR

T1 - Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them

AU - Liou, Bi Jiuan

AU - Chang, Hsun Shuo

AU - Wang, Guei Jane

AU - Chiang, Michael Y.

AU - Liao, Chang Hui

AU - Lin, Chu Hung

AU - Chen, Ih Sheng

PY - 2011/4

Y1 - 2011/4

N2 - Seven sesquiterpenoids, hiiranlactones A-D (1-4), (-)-ent-6α- methoxyeudesm-4(15)-en-1β-ol (5), (+)-villosine (6), hiiranepoxide (7), and one triterpenoid, hiiranterpenone (8), together with 22 known compounds, were isolated from the leaves of Neolitsea hiiranensis (Lauraceae). Their structures were elucidated by spectroscopic analysis and single crystal X-ray diffraction. Among the isolates, hiiranlactone B (2) and hiiranlactone D (4) exhibited inhibitory activity against fMLP-induced superoxide production by human neutrophils with IC50 values of 21.86 ± 3.97 and 25.78 ± 4.77 μM, respectively.

AB - Seven sesquiterpenoids, hiiranlactones A-D (1-4), (-)-ent-6α- methoxyeudesm-4(15)-en-1β-ol (5), (+)-villosine (6), hiiranepoxide (7), and one triterpenoid, hiiranterpenone (8), together with 22 known compounds, were isolated from the leaves of Neolitsea hiiranensis (Lauraceae). Their structures were elucidated by spectroscopic analysis and single crystal X-ray diffraction. Among the isolates, hiiranlactone B (2) and hiiranlactone D (4) exhibited inhibitory activity against fMLP-induced superoxide production by human neutrophils with IC50 values of 21.86 ± 3.97 and 25.78 ± 4.77 μM, respectively.

KW - Anti-inflammatory activity

KW - Lauraceae

KW - Leaves

KW - Neolitsea hiiranensis

KW - Sesquiterpenoid

KW - Triterpenoid

UR - http://www.scopus.com/inward/record.url?scp=79952190897&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2011.01.006

DO - 10.1016/j.phytochem.2011.01.006

M3 - 文章

C2 - 21295319

AN - SCOPUS:79952190897

SN - 0031-9422

VL - 72

SP - 415

EP - 422

JO - Phytochemistry

JF - Phytochemistry

IS - 4-5

ER -

Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them

Abstract

Keywords

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