Secondary metabolites from the root of Ehretia longiflora and their biological activities

Yu Chieh Chien; Chu Hung Lin; Michael Y. Chiang; Hsun Shuo Chang; Chang Hui Liao; Ih Sheng Chen; Chien Fang Peng; Ian Lih Tsai

doi:10.1016/j.phytochem.2012.04.013

Secondary metabolites from the root of Ehretia longiflora and their biological activities

Yu Chieh Chien, Chu Hung Lin, Michael Y. Chiang, Hsun Shuo Chang, Chang Hui Liao, Ih Sheng Chen, Chien Fang Peng, Ian Lih Tsai^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

29 Scopus citations

Abstract

Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds, ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 μg/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC ₅₀ value of 0.36 ± 0.03 μM.

Original language	English
Pages (from-to)	50-57
Number of pages	8
Journal	Phytochemistry
Volume	80
DOIs	https://doi.org/10.1016/j.phytochem.2012.04.013
State	Published - 08 2012

Keywords

Anti-inflammatory activity
Antitubercular activity
Boraginaceae
Ehretia longiflora
Root

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytochem.2012.04.013

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@article{18c49a8390224355b16b26916f03d4a3,

title = "Secondary metabolites from the root of Ehretia longiflora and their biological activities",

abstract = "Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds, ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 μg/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC 50 value of 0.36 ± 0.03 μM.",

keywords = "Anti-inflammatory activity, Antitubercular activity, Boraginaceae, Ehretia longiflora, Root",

author = "Chien, {Yu Chieh} and Lin, {Chu Hung} and Chiang, {Michael Y.} and Chang, {Hsun Shuo} and Liao, {Chang Hui} and Chen, {Ih Sheng} and Peng, {Chien Fang} and Tsai, {Ian Lih}",

year = "2012",

month = aug,

doi = "10.1016/j.phytochem.2012.04.013",

language = "英语",

volume = "80",

pages = "50--57",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd",

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T1 - Secondary metabolites from the root of Ehretia longiflora and their biological activities

AU - Chien, Yu Chieh

AU - Lin, Chu Hung

AU - Chiang, Michael Y.

AU - Chang, Hsun Shuo

AU - Liao, Chang Hui

AU - Chen, Ih Sheng

AU - Peng, Chien Fang

AU - Tsai, Ian Lih

PY - 2012/8

Y1 - 2012/8

N2 - Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds, ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 μg/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC 50 value of 0.36 ± 0.03 μM.

AB - Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds, ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 μg/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC 50 value of 0.36 ± 0.03 μM.

KW - Anti-inflammatory activity

KW - Antitubercular activity

KW - Boraginaceae

KW - Ehretia longiflora

KW - Root

UR - http://www.scopus.com/inward/record.url?scp=84863629596&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2012.04.013

DO - 10.1016/j.phytochem.2012.04.013

M3 - 文章

C2 - 22626966

AN - SCOPUS:84863629596

SN - 0031-9422

VL - 80

SP - 50

EP - 57

JO - Phytochemistry

JF - Phytochemistry

ER -

Secondary metabolites from the root of Ehretia longiflora and their biological activities

Abstract

Keywords

UN SDGs

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